39718-32-6

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Difluorophenyl isocyanate is used as a key intermediate for the synthesis of potential antiatherosclerotic agents, which are crucial in the treatment and prevention of atherosclerosis, a condition characterized by the hardening and narrowing of arteries.
Used in Chemical Synthesis:
As an aryl fluorinated building block, 2,5-Difluorophenyl isocyanate is used as a starting material or intermediate in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its unique chemical properties allow for the development of novel molecules with specific biological activities or improved properties.

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 367-30-6 2,5-difluoroaniline 
• 75-44-5 phosgene 

Downstream Products

• 919120-25-5 C₂₆H₃₄F₂N₄O₂ 
• 919120-24-4 C₂₆H₃₄F₂N₄O₂ 
• 1384460-76-7 diethyl 4-(4-(3-(2,5-difluorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1620784-91-9 C₁₂H₁₀F₂N₄O₂ 
• 1620784-67-9 C₁₃H₁₂F₂N₄O₃ 
• 1620784-51-1 C₁₂H₉ClF₂N₄O 
• 1620784-27-1 N-(2,5-difluorophenyl)-N'-(2-aminopyrimidyl)urea 
• 1620784-07-7 C₁₂H₉ClF₂N₄O₂ 

Relevant academic research and scientific papers

N-fluorinated phenyl-N′-pyrimidyl urea derivatives: Synthesis, biological evaluation and 3D-qsar study

With the increase of herbicide-resistant weeds, novel, more selective and even more potent herbicides to control weeds are needed. In this paper, a series of N-fluorinated phenyl-N′-pyrimidyl urea derivatives were synthesized and screened for their herbicidal activities against Amaranthus retroflexus (AR) and Setaria viridis (SV). Compound 25 (N-(3-trifluoromethylphenyl)-N′-(2- amino-4-chloro-6-methylpyrimidyl) urea) exhibited marked herbicidal activity against SV (IC50 = 11.67 mg/L) and is more potent than bensulfuron (IC50 = 27.45 mg/L), a commercially available herbicide. A statistically significant CoMFA model with high prediction abilities (q 2 = 0.869, r2 = 0.989) was obtained.

Organosilicon synthesis of isocyanates: I. Synthesis of isocyanates of the furan, thiophene, and mono-and polyfluorophenyl series

A convenient synthesis of known and unknown isocyanates of the furan, thiophene, and mono-and polyfluorophenyl series, involving silylation of starting amines with hexamethyldisilazane or chlorotrimethylsilane, followed by phosgenation of the resulting N-silyl-substituted amines. An unusual high-temperature rearrangement of 3-(methoxycarbonyl)-4,5-dimethylthiophene-2-yl isocyanate into its 5-ethyl isomer. ortho-Fluorine substituent in anilines decreases the yield of isocyanates, whereas 2,3,5,6-tetrafluorophenyl isocyanate exists for only a short time as a 5% toluene solution. Pleiades Publishing, Inc. 2006.