39727-75-8Relevant academic research and scientific papers
Synthesis and properties of hole-transporting triphenylamine-derived dendritic compounds
Reghu, Renji R.,Simokaitiene, Jurate,Grazulevicius, Juozas V.,Raisys, Steponas,Kazlauskas, Karolis,Jursenas, Saulius,Jankauskas, Vygintas,Reina, Antonio
, p. 135 - 142 (2015/03/05)
Materials based on triphenylamino core linked with different alkoxyphenyl-substituents through olefinic spacers were synthesised, and their thermal, photophysical and photoelectrical properties were investigated. The synthesized compounds showed relativel
Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis
Petch, Donna,Anderson, Rosaleen J.,Cunningham, Anne,George, Suja E.,Hibbs, David E.,Liu, Ran,MacKay, Simon P.,Paul, Andrew,Small, David A.P.,Groundwater, Paul W.
, p. 5901 - 5914 (2012/11/06)
Hit compounds from in silico screening for inhibitors of the EGFR dimerization process were evaluated for their anti-proliferative (CCD-1106 keratinocytes) and anti-oxidant (TBA assay) activity and their effect on EGFR dimerization (BS3 chemical crosslinking assay). 7-Benzyl-8-{N′- [1-(3-ethoxy-4-hydroxyphenyl)meth-(Z)-ylidene]hydrazino}-1,3-dimethylxanthine 2a (127 μM) leads to 37% inhibition of p-EGFR dimerization in the CCD-1106 cell line and also inhibits phosphorylation of proteins in the MAPK/ERK pathway, ERK 1/2 and p-38. Based on this initial data, 2a was selected for further study and was evaluated for its anti-proliferative activity in a range of keratinocyte (CCD-1106, HaCaT and NHEK) and monocyte (ThP1 and U937) cell lines. Xanthine 2a is pro-apoptotic in HaCaT keratinocytes, as shown by electron microscopy, caspase 3/7, and annexin V-FITC/PI flow cytometric assays. It is significantly less cytotoxic than the established antipsoriatic agent dithranol 14, as determined by MTT and LDH release assays, and thus has potential as a lead compound for the treatment of psoriasis.
Influence of alkoxy tail length on the phase behaviour of mesogen-jacketed liquid crystalline polymers with fan-shaped pendants
Yang, Chang-An,Wang, Guo,Xie, He Lou,Zhang, Hai Liang
experimental part, p. 4503 - 4510 (2011/11/06)
A series of new monomers of 2, 5-bis [(3, 4, 5-trialkoxy benzyl) oxycarbonyl] styrene (denoted as M-tri-OCmH2m + 1, m = 1, 2, 4, 6, 8, 10, 12, where m indicated the number of carbon atoms in the alkoxy group) were designed and synthesized. Then, their corresponding polymers P-tri-OCmH2m + 1 (m = 1, 2, 4, 6, 8, 10, 12) were synthesized by free radical polymerization. The chemical structure of the monomers was confirmed by elemental analysis, 1H NMR and 13C NMR. The molecular characterization of polymers was performed with 1H NMR, gel permeation chromatography (GPC). The thermal stability of polymers was investigated by thermogravimetric analysis (TGA). The phase structure and transition behaviours were studied using differential scanning calorimetry (DSC), polarized light microscopy (PLM), one- and two-dimensional (1D and 2D) wide-angle X-ray diffraction (WAXD). We found that P-tri-OCmH2m + 1 (m = 1, 2) with short n-alkoxy substituents as the tail form columnar nematic (ΦN) phase; that with the increasing length of alkoxy tails, P-tri-OCmH2m + 1 (m = 4, 6, 8) can demonstrate the hexagonal columnar (ΦH) phase; however, when the length of alkoxy tails exceeded a threshold, P-tri-OCmH2m + 1 (m = 10, 12) only develop into columnar nematic (ΦN) phase instead of ΦH phase.
Sulfur Analogues of Psychotomimetic Agents. 3. Ethyl Homologues of Mescaline and Their Monothio Analogues
Jacob, Peyton,Shulgin, Alexander T.
, p. 881 - 888 (2007/10/02)
All possible monothio analogues of the mono-, di-, and triethoxy homologues of mescaline have been synthesized and pharmacologically evaluated in man.Modifications at the ring position para to the ethylamine chain, either with a sulfur atom, a longer alkyl chain, or both, lead to compounds of high central nervous system activity.The 4-n-propoxy and 4-n-butoxy homologues and their corresponding 4-thio analogues were also synthesized and pharmacologically evaluated.The propyl homologues retain high potency, but a butyl group (either with or without a sulfur atom) leads to a decrease in activity.The m-ethyl or m-thio analogues retain some central action but the diethoxy and especially the triethoxy homologues are relatively inactive as psychotomimetic drugs.
