6970-19-0

Usage

InChI:InChI=1/C13H18O5/c1-4-16-10-7-9(13(14)15)8-11(17-5-2)12(10)18-6-3/h7-8H,4-6H2,1-3H3,(H,14,15)/p-1

Upstream product

• 64-67-5 diethyl sulfate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 861320-32-3 3,5,7-triethoxy-2-(3,4,5-triethoxy-phenyl)-chromen-4-one 
• 39666-77-8 methyl 3,4,5-triethoxybenzoate 
• 99-24-1 methyl galloate 

Downstream Products

• 102708-87-2 3,4,5-triethoxy-benzoic acid-(2-diethylamino-ethyl ester) 
• 90132-55-1 2,6-diethoxyphenol 
• 50915-97-4 3,4,5-triethoxybenzoyl chloride 
• 31374-71-7 3,4,5-triethoxybenzoic acid ethyl ester 
• 1147-81-5 3',4',5'-Triaethoxy-acetophenon 
• 90109-63-0 3,4,5-triethoxyphenethylamine 
• 860724-22-7 3,4,5-triethoxybenzaldehyde 
• 184963-78-8 3',4',5'-triethoxypropiophenone 
• 330671-56-2 5-(2,4-dichlorophenyl)-2-furylmethyl 3,4,5-triethoxybenzoate 
• 1365714-28-8 5-(4-methylphenyl)-2-furylmethyl 3,4,5-triethoxybenzoate 
• 1365714-26-6 5-(4-nitrophenyl)-2-furylmethyl 3,4,5-triethoxybenzoate 
• 1365714-23-3 5-(4-phenyl)-2-furylmethyl 3,4,5-Triethoxybenzoate 
• 1613027-19-2 4,5,6-tris(benzyloxy)-2-phenylisoindoline-1,3-dione 

Relevant academic research and scientific papers

DIARYL TREHALOSE COMPOUNDS AND USES THEREOF

Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Molecular control of macroscopic cubic, columnar, and lamellar organizations in luminescent lanthanide-containing thermotropic liquid crystals

The connection of lipophilic gallic acid derivatives at the 5,5′- or 6,6′-positions of the rigid 2,6-bis(1-ethyl-benzimidazol-2-yl)pyridine core provides two pro-mesogenic tridentate ligands L10 and L12, whose molecular shapes, anisometries, and directional intermolecular π-stacking can be tuned. X-ray diffraction data in the crystalline state, combined with solution 1H NMR measurements, show that complexation with trivalent lanthanides, Ln(III), produces the neutral hemi-disklike complexes [Ln(Li)(NO3)3] (i = 10, 12), which dimerize to give the rodlike bimetallic complexes [Ln2(Li)2(NO 3)6] at lower temperature. The relevant thermodynamic parameters for the latter process depend on the nature of the ligand, the size of the metal ion, and the strength of the intermolecular interactions involved in the condensed phase. These three-dimensional models obtained for the complexes in the crystals and in solution are eventually confronted with small-angle XRD profiles recorded in the intermediate thermotropic liquid crystalline phase, in which the rigidity of the packed polyaromatic cores is maintained, while the alkyl chains are molten. According to the specific geometries and nuclearities of the molecular complexes, three types of mesophases (lamellar, columnar, and cubic) can be induced, which provides a direct correlation between the microscopic arrangements and the macroscopic ordering in lanthanide-containing metallomesogens.

Depigmenting activity and low cytotoxicity of alkoxy benzoates or alkoxy cinnamte in cultured melanocytes

To obtain effective and safe topical depigmenting agents, we synthesized hydroxybenzoates, alkoxybenzoates, and 3,4,5-trimethoxycinnamate containing a thymol moiety and screened then for high-level inhibitory activity against melanin synthesis in cultured melanocytes. Eight compounds were tested for their depigmenting effect and cytotoxicity using a murine melanocyte cell line. We found that 3,4,5-trialkoxybenzoates and 3,4,5-trimethoxycinnamate, synthesized by conjugating 3,4,5-trialkoxybenzoic acids and 3,4,5-trimethoxycinnmic acid with thymol, showed a potent depigmenting effect and low cytotoxicity. Compound 4h, 5-methyl-2-(methylethyl)phenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate, showed the most potent depigmenting effect (IC50=10 μM) with low cytotoxicity (IC50=200 μM).