397275-34-2

Basic information

• Product Name: Benzaldehyde, 4-[[1-(1-methylethyl)-4-piperidinyl]oxy]-
• CAS NO: 397275-34-2
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.337
• Mol File: 397275-34-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[[1-(1-methylethyl)-4-piperidinyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[[1-(1-methylethyl)-4-piperidinyl]oxy]-(397275-34-2)
• EPA Substance Registry System: Benzaldehyde, 4-[[1-(1-methylethyl)-4-piperidinyl]oxy]-(397275-34-2)

Safety Data

• Hazardous Substances Data: 397275-34-2(Hazardous Substances Data)

Upstream product

• 397275-42-2 4-[(1-isopropyl-4-piperidinyl)oxy]benzonitrile 
• 5355-68-0 1-Isopropyl-4-piperidone 
• 5570-78-5 1-isopropylpiperidin-4-ol 

Relevant articles and documents

4-Phenoxypiperidines: Potent, conformationally restricted, non-imidazole histamine H3 antagonists

Two new series of 4-(1-alkyl-piperidin-4-yloxy)-benzonitriles and 4-(1-isopropyl-piperidin-4-yloxy)-benzylamines have been prepared. In vitro activity was determined at the recombinant human H3 receptor and several members of these new series were found to be potent H3 antagonists. The present compounds contain a 4-phenoxypiperidine core, which behaves as a conformationally restricted version of the 3-amino-1-propanol moiety common to the many previously described non-imidazole histamine H 3 ligands. One selected member of the new series, 4-[4-(1-isopropyl-piperidin-4-yloxy)-benzyl]-morpholine (13g), was found to be a potent, highly selective H3 receptor antagonist with in vivo efficacy in a rat EEG model of wakefulness at doses as low as 1 mg/kg sc.