5355-68-0

Basic information

• Product Name: 1-Isopropyl-4-piperidone
• Synonyms: 1-(1'-METHYLETHYL)-4-PIPERIDONE;1-ISOPROPYL-4-PIPERIDONE;1-ISOPROPYL-PIPERIDIN-4-ONE;TIMTEC-BB SBB005846;1-Isopropyl-4-piperidinone;4-Piperidinone, 1-(1-methylethyl)-;4-Piperidinone,1-(1-methylethyl)-;4-Piperidone, 1-isopropyl-
• CAS NO: 5355-68-0
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• EINECS: 226-339-6
• Product Categories: Piperidine;Heterocyclic Compounds
• Mol File: 5355-68-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 105-105.5 °C
• Boiling Point: 100-101 °C (27 mmHg)
• Flash Point: 100-101°C/27mm
• Appearance: clear yellow to brown liquid
• Density: 0.95
• Refractive Index: 1.465-1.467
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.18±0.20(Predicted)
• BRN: 107857
• CAS DataBase Reference: 1-Isopropyl-4-piperidone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Isopropyl-4-piperidone(5355-68-0)
• EPA Substance Registry System: 1-Isopropyl-4-piperidone(5355-68-0)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 45-36/37/39-26-36-37
• Hazardous Substances Data: 5355-68-0(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 53601-94-8 4-oxo-piperidine-1,3-dicarboxylic acid diethyl ester 
• 83783-66-8 Ethyl N-ethoxycarbonyl-3-(2-ethoxycarbonylethylamino)-propionate 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 
• 41661-47-6 piperidin-4-one 
• 75-30-9 2-iodo-propane 
• 26822-37-7 N,N-dimethyl-4-oxopiperidinium iodide 
• 75-31-0 isopropylamine 
• 1445-73-4 1-Methyl-4-piperidone 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 76360-19-5 N-isopropyl bis (2-(ethoxycarbonyl)ethyl)amine 
• 16217-23-5 3,3'-isopropylimino-di-propionic acid diethyl ester 

Downstream Products

• 797751-17-8 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester 
• 74022-41-6 2-Benzylaminomethyleneamino-3-cyano-4,5,6,7-tetrahydro-6-isopropylthieno<3,4-b>pyridine 
• 74022-36-9 2-Benzoyl-amino-3-ethoxycarbonyl-4,5,6,7-tetrahydro-6-isopropylthieno<3,4-b>pyridine 
• 74022-37-0 2-p-Chlorobenzoyl-amino-3-ethoxycarbonyl-4,5,6,7-tetrahydro-6-isopropylthieno<3,4-b>pyridine 
• 74022-38-1 2-Phenyl-5,6,7,8-tetrahydro-7-isopropylpyrido<4',3':4,5>thieno<2,3-d>pyrymidin-4(3H)-one 
• 74022-42-7 2-Benzylamino-5,6,7,8-tetrahydro-7-isopropylpyrido<4',3':4,5>thieno<2,3-d>pyrimidine 
• 74022-39-2 2-p-Chlorophenyl-5,6,7,8-tetrahydro-7-isopropylpyrido<4',3':4,5>thieno<2,3-d>pyrimidin-4(3H)-one 
• 503126-34-9 (1-isopropyl-piperidin-4-yl)-methyl-amine 
• 135834-53-6 7-(4'-Chlorobenzyl)-3-isopropyl-3,7-diazabicyclo[3.3.1]nonan-9-one 
• 123099-50-3 3-isopropyl-7-benzyl-3,7-diazabicyclo[3.3.1]nonan-9-one 
• 73109-88-3 2-(N-Isopropyl-1,2,3,6-tetrahydro-4-pyridyl)-5-isopropyl resorcinol hydrochloride 
• 912947-64-9 4-(1-Isopropyl-piperidin-4-ylidenemethyl)-benzoic acid 
• 327168-35-4 10-amino-9-aza-3-azonia-7,11-dicyano-3-isopropylspiro[5,5]undeca-7,10-diene-8-thiolate 
• 1401995-11-6 8-isopropyl-3-methyl-2-oxo-1-oxa-8-aza-spiro[4.5]dec-3-ene-4-carboxylic acid 2-tert-butoxy-5-trifluoromethyl-benzylamide 

Relevant articles and documents

Synthesis method of bacterial infection resistant medicine intermediate

The invention belongs to the technical field of chemical medicine intermediate synthesis, and particularly relates to a synthesis method of a bacterial infection resistant medicine intermediate. Liquid ammonia and acrylic ester are used as raw materials for preparing a diester type secondary amine compound 1; then, through cyclization, piperidone is prepared; then, scientific reaction catalysts, temperature and time are used; substitution reaction of secondary amine and iso-propyl iodide is used; the target product is synthesized through six-step reaction; the yield of the whole route reachesup to 35 percent.

SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

Synthesis of heteroarylpiperazines and heteroarylbipiperidines with a restricted side chain and their affinities for 5-HT1A receptor

Heteroarylpiperazine and heteroarylbipiperidine derivatives, bearing a 4-piperidine ring instead of an alkylamino side chain to give the semi-rigidity, were prepared and evaluated for their abilities to displace [3H] 8-OH-DPAT binding to the rat hippocampal synaptic membranes. These compounds showed low to moderate affinities for 5-HT1A receptor, with Ki values ranging from 6912 nM to 232 nM. Of these compounds, 8 b and 15 e exhibited the best affinities for 5-HT1A receptor with Ki values of 232 nM and 338 nM, respectively.