39728-43-3

Upstream product

• 31664-87-6 2-cyano-1,3-dimethyl-5-nitrobenzene 
• 90564-17-3 2,6-dimethyl-4-nitrobenzoic acid 

Downstream Products

• 94964-45-1 Di-(2,6-dimethyl-4-nitrobenzoyl)-glycerin-α-iod-hydrin 
• 100170-23-8 Di-(2,6-dimethyl-4-nitrobenzoyl)-glycerin-β-iodhydrin 
• 90564-17-3 2,6-dimethyl-4-nitrobenzoic acid 
• 39728-42-2 1-(2,6-dimethyl-4-nitro-benzoyl)-aziridine 
• 74669-63-9 4-(2,6-Dimethyl-4-nitrobenzoyloxy)pyridin 
• 85374-87-4 2,6-Dimethyl-4-nitrobenzoesaeure-trifluormethansulfonsaeure-anhydrid 
• 85374-82-9 2,6-Dimethyl-4-nitrobenzoesaeure-methansulfonsaeure-anhydrid 
• 936027-37-1 4-(4-amino-3,5-dimethyl-phenyl)-4-[4-(2,6-dimethyl-4-nitro-benzoylamino)-3,5-dimethyl-phenyl]-piperidine-1-carboxylic acid benzyl ester 
• 936027-46-2 4-(4-benzyloxycarbonylamino-3,5-dimethyl-phenyl)-4-{4-[(2,6-dimethyl-4-nitrobenzoyl)-methyl-amino]-3,5-dimethyl-phenyl}-piperidine-1-carboxylic acid benzyl ester 
• 104374-02-9 4-amino-2,6-dimethyl-N-<2-<4-(2-pyridinyl)-1-piperazinyl>ethyl>benzamide 
• 104374-03-0 2,6-dimethyl-4-nitro-N-<2-<4-(2-pyridinyl)-1-piperazinyl>ethyl>benzamide 
• 1105057-33-7 2,6-dimethyl-4-nitrobenzoic anhydride 
• 936027-43-9 N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide 
• 936027-41-7 4-[4-(2,6-dimethyl-4-nitro-benzoylamino)-3,5-dimethyl-phenyl]-4-{3,5-dimethyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-phenyl}-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

2,6-Dimethyl-4-nitrobenzoic anhydride (DMNBA): An effective coupling reagent for the synthesis of carboxylic esters and lactones

Various carboxylic esters are obtained at room temperature in excellent yields with high chemoselectivities from nearly equimolar amounts of carboxylic acids and alcohols using 2,6-dimethyl-4-nitrobenzoic anhydride with triethylamine by the promotion of 4-(dimethylamino)pyridine. The efficiency of the esterification is compared to those of other dehydrations using substituted benzoic anhydrides as coupling reagents. This method was successfully applied to the synthesis of threo-aleuritic acid lactone and the desired 17-membered ring compound was prepared in high yield at room temperature from the corresponding free trihydroxycarboxylic acid using 2,6-dimethyl-4-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine.

Substituent effects on aromatic stacking interactions

Synthetic supramolecular zipper complexes have been used to quantify substituent effects on the free energies of aromatic stacking interactions. The conformational properties of the complexes have been characterised using NMR spectroscopy in CDCl3, and by comparison with the solid state structures of model compounds. The structural similarity of the complexes makes it possible to apply the double mutant cycle method to evaluate the magnitudes of 24 different aromatic stacking interactions. The major trends in the interaction energy can be rationalised using a simple model based on electrostatic interactions between the π-faces of the two aromatic rings. However, electrostatic interactions between the substituents of one ring and the π-face of the other make an additional contribution, due to the slight offset in the stacking geometry. This property makes aromatic stacking interactions particularly sensitive to changes in orientation as well as the nature and location of substituents. This journal is The Royal Society of Chemistry.