397323-70-5

Usage

Uses

Used in Pharmaceutical Industry:
(2-Amino-3-bromophenyl)methanol is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure, which includes a bromine atom, an amino group, and a hydroxyl group, allows it to be a key component in the creation of new drugs targeting different medical conditions.
Used in Organic Synthesis:
In the field of organic chemistry, (2-Amino-3-bromophenyl)methanol is utilized as a building block for synthesizing a variety of organic compounds. Its versatility in undergoing different chemical reactions makes it a valuable asset for creating complex organic molecules with specific properties and applications.
It is crucial to handle (2-Amino-3-bromophenyl)methanol with care and adhere to safety protocols during its use, as it may present hazardous effects if not properly managed.

Upstream product

• 20776-51-6 2-amino-3-bromo benzoic acid 

Relevant academic research and scientific papers

2 - Formyl quinoline carboxamide compound and medical application thereof

The invention relates to 2 - formyl quinoline carboxamide compound and medical application thereof, and the structure is shown in a formula (I). The invention further relates to a preparation method of the compound. Use of a pharmaceutical composition and

BICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

KRAS G12C INHIBITORS AND METHODS OF USING THE SAME

Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

BICYCLIC COMPOUNDS AS INHIBITORS OF PD1/PD-L1 INTERACTION/ACTIVATION

The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are bicyclic compounds that are inhibitors of PD-1/PD-L1 interaction/activation.

Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

ANTIVIRAL COMPOUNDS

The invention is related to HCV inhibitory compounds, compositions containing such compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds (I).

FIBROSIS INHIBITOR

Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is -CO-, -SO2-, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2):(1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms:(2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.

Pyrrole derivatives

Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W2 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.