397323-70-5Relevant articles and documents
2 - Formyl quinoline carboxamide compound and medical application thereof
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Paragraph 0114; 0121; 0127-0129, (2021/12/07)
The invention relates to 2 - formyl quinoline carboxamide compound and medical application thereof, and the structure is shown in a formula (I). The invention further relates to a preparation method of the compound. Use of a pharmaceutical composition and
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
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Paragraph 0775-0776, (2019/12/30)
Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid
Li, Jianjun,Fu, Yiwei,Qin, Cong,Yu, Yang,Li, Hao,Wang, Wei
supporting information, p. 6474 - 6477 (2017/08/16)
A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.