39736-26-0

Usage

Uses

Used in Pharmaceutical Research:
1-[4-AMINO-2-(METHYLSULFANYL)-1,3-THIAZOL-5-YL]ETHANONE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential biological activities. Its unique structure allows for the development of new drugs with novel mechanisms of action.
Used in Organic Synthesis:
In the field of organic synthesis, 1-[4-AMINO-2-(METHYLSULFANYL)-1,3-THIAZOL-5-YL]ETHANONE serves as a versatile building block for the creation of complex organic molecules. Its reactivity and functional groups enable the formation of a wide range of chemical products.
Used in Agrochemical Development:
1-[4-AMINO-2-(METHYLSULFANYL)-1,3-THIAZOL-5-YL]ETHANONE is also utilized in the development of agrochemicals, where its potential biological activities can be harnessed for applications such as pest control and crop protection.
Used in Chemical Research:
In the realm of chemical research, 1-[4-AMINO-2-(METHYLSULFANYL)-1,3-THIAZOL-5-YL]ETHANONE is employed as a subject of study to explore its properties, reactivity, and potential applications in various chemical processes and reactions.
Note: Since the provided materials do not specify particular industries or reasons for the uses of 1-[4-AMINO-2-(METHYLSULFANYL)-1,3-THIAZOL-5-YL]ETHANONE, the applications listed are general and based on the compound's potential properties and activities.

InChI:InChI=1/C6H8N2OS2/c1-3(9)4-5(7)8-6(10-2)11-4/h7H2,1-2H3

Upstream product

• 78-95-5 chloroacetone 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 
• 98142-61-1 3-iodopentane-2,4-dione 
• 10191-61-4 potassium S-methyl N-cyanocarbamodithioate 
• 1694-29-7 3-chloropentane-2,4-dione 
• 2198-65-4 2-bromo-3-oxo-N-phenylbutanamide 
• 3043-28-5 3-bromopentane-2,4-dione 
• 82060-31-9 C₃H₆N₄O₂S₂ 

Relevant academic research and scientific papers

ANTI-INFECTIVE COMPOUNDS

The present invention relates to small molecule compounds having the general formula (I): wherein A is a moiety selected from the group consisting of formulae (A) to (K) and their use in the treatment of bacterial infections, in particular Tuberculosis.

NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts

A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN

4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells

The in vitro growth inhibitory activity of 26 thiazoles (including 4-halogeno-2,5-disubtituted-1,3-thiazoles) and 5 thienothiazoles was assessed on a panel of 6 human cancer cell lines, including glioma cell lines. (4-Chloro-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12a) and (4-bromo-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12b) displayed ～10 times greater in vitro growth inhibitory activity than perillyl alcohol (POH), which therapeutically benefits glioma patients through the inhibition of both alpha-1 Na+/K+-ATPase (NAK) and Ras oncogene activity. The in vitro cytostatic activities (as revealed by quantitative videomicroscopy) displayed by 12a and 12b were independent of the intrinsic resistance to pro-apoptotic stimuli associated with cancer cells. Compounds 12a and 12b displayed relatively similar inhibitory activities on purified guinea pig brain preparations that mainly express NAK alpha-2 and alpha-3 subunits, whereas only compound 12b was efficacious against purified guinea pig kidney preparations that mainly express the NAK alpha-1 subunit, which is also expressed in gliomas, melanomas and non-small-cell lung cancers NSCLCs.

Heterocondensed thiophenes and thiazoles by Thorpe-Ziegler cyclization

(Chemical Equation Presented) The syntheses of novel thieno-pyridones, thiazolo-pyridones, thiazolo-pyridines and amino- and diamino-dieno-pyridines were described. Simultaneously, it was demonstrated that in these compounds and in the related 3-aminothio

A New Synthesis of Substituted 4-Amino-1,3-thiazoles

In the 5-position substituted 4-amino-2-alkylthio-1,3-thiazoles are prepared in good yields from N-nitro-amidino-dithiocarbamates 1 and α-halogen-carbonylcompounds or chloracetonitrile. 1 reacts with 1,3-dichlor-acetone under formation of adequate bis(1,3