39739-60-1Relevant articles and documents
Naturally Occurring Linear Fused Thiazoline-Thiazole Containing Metabolites: Total Synthesis of (-)-Didehydromirabazole A, a Cytotoxic Alkaloid from Blue-Green Algae
Pattenden, Gerald,Thom, Stephen M.
, p. 1629 - 1636 (1993)
A concise total synthesis of the thiazoline-thiazole containing metabolite didehydromirabazole A 1 is described.The synthesis uses the unusual amino acid (R)-2-methylcysteine 20 in sequential cyclocondensations with imino ethers as key steps, viz 22 -> 32 and 37 -> 38.
FUNGICIDAL HETEROCYCLIC COMPOUNDS
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Page/Page column 58, (2010/11/24)
A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.
A facile and versatile route to 2-substituted-4(3H)-quinazolinones and quinazolines
Connolly,Guiry
, p. 1707 - 1710 (2007/10/03)
A range of 2-aryl and 2-alkyl quinazolinones have been prepared in moderate to good yields from the reaction of anthranilic acid and the appropriately substituted imidate in a facile, mild, onepot procedure. Subsequent reaction with phosphorus oxychloride afforded the corresponding 4-chloro-2-substituted quinazolines, which are useful synthetic intermediates, in good to high yields. Product isolation was facilitated by the development of work up procedures for both reactions that did not include purification by column chromatography.