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1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-(2-methylpropyl)-, also known as 5-hydroxy-2-isobutylphthalimide, is an organic compound with the molecular formula C12H13NO3. It is a derivative of phthalimide, featuring a hydroxyl group at the 5-position and an isobutyl group at the 2-position. 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-(2-methylpropyl)- is characterized by its white crystalline appearance and is soluble in organic solvents. It is synthesized through various chemical reactions and is used in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. The compound's unique structure and properties make it a valuable intermediate in the synthesis of various compounds, particularly those with potential therapeutic applications.

3975-52-8

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3975-52-8 Usage

Structure

A derivative of isoindole with a hydroxy group and a 2-methylpropyl side chain

Pharmaceutical applications

Potential antifungal and anti-inflammatory properties, possible dopamine receptor antagonist

Need for further research

To fully understand the biological activities and potential uses of this chemical compound.

Check Digit Verification of cas no

The CAS Registry Mumber 3975-52-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,7 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3975-52:
(6*3)+(5*9)+(4*7)+(3*5)+(2*5)+(1*2)=118
118 % 10 = 8
So 3975-52-8 is a valid CAS Registry Number.

3975-52-8Relevant academic research and scientific papers

Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

Dhanya, Raveendra-Panickar,Sidique, Shyama,Sheffler, Douglas J.,Nickols, Hilary Highfield,Herath, Ananda,Yang, Li,Dahl, Russell,Ardecky, Robert,Semenova, Svetlana,Markou, Athina,Conn, P. Jeffrey,Cosford, Nicholas D. P.

experimental part, p. 342 - 353 (2011/03/18)

The modification of 3′-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3- dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with optimized potency and superior druglike properties. These analogues are more potent than 1 in vitro and are highly selective for mGluR2 vs other mGluR subtypes. They have significantly improved pharmacokinetic (PK) properties, with excellent oral bioavailability and brain penetration. The benzisothiazol-3-one derivative 14 decreased cocaine self-administration in rats, providing proof-of-concept for the use of mGluR2 PAMs for the treatment of cocaine dependence.

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