39756-29-1Relevant academic research and scientific papers
I(2)-imidazoline binding site affinity of a structurally different type of ligands.
Dardonville, Christophe,Rozas, Isabel,Callado, Luis F,Meana, J Javier
, p. 1525 - 1533 (2002)
Two families of compounds with affinity towards the I(2) imidazoline binding sites are reported. The first is a family of compounds structurally related to agmatine with two guanidine or 2-aminoimidazoline groups at each end of an aliphatic chain of six,
Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor
Villarroya, Mercedes,Gandia, Luis,Lopez, Manuela G.,Garcia, Antonio G.,Cueto, Senida,Garcia-Navio, Jose-Luis,Alvarez-Builla, Julio
, p. 1177 - 1183 (2007/10/03)
Taking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,ω-diguanidinium salts were obtained. Some of them blocked ion fluxes through the neuronal nicotinic receptors for acetylcholine (nAChR). The blockade was exerted at submicromolar concentrations, suggesting a highly selective interaction with the nAChR. In fact, the active compounds on the nAChR ion channel did not recognize the voltage-dependent Na+ or Ca2+ channels of bovine adrenal chromaffin cells. Therefore, these compounds may be useful tools to clarify the functions of nAChR receptors in the central and peripheral nervous systems.
