39765-16-7

Upstream product

• 154633-82-6 7-{(1S,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-oxo-cyclopentyl}-heptanoic acid methyl ester 
• 84019-03-4 1-phenylthio-2-octene 
• 25152-84-5 trans,trans-2,4-decadienal 
• 83344-02-9 (7-Iodo-heptylsulfanyl)-benzene 
• 111-66-0 oct-1-ene 
• 133496-31-8 (1'E)-6-(3'-hydroxy-1'-octenyl)-5-(6-carbomethoxyhexyl)-2,2-dimethyl-3aβ,5,6α,6aβ-tetrahydro-4H-cyclopenta-1,3-dioxol-4-one 
• 86982-75-4 7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-oxo-cyclopentyl}-heptanoic acid methyl ester 
• 133230-25-8 methyl (1''E,7E)-7-<6'-<3''-(tert-butyldimethylsiloxy)-1''-octenyl>-2',2'-dimethyl-4'-oxo-3'aβ,5',6'α,6'aβ-tetrahydro-4'H-cyclopenta-1',3'-dioxol-5'-ylidene>heptanoate 
• 133496-27-2 (1'E)-6-<3'-(tert-butyldimethylsiloxy)-1'-octenyl>-5-(6-carbomethoxyhexyl)2,2-dimethyl-3aβ,5,6α,6aβ-tetrahydro-4H-cyclopenta-1,3-dioxol-4-one 
• 133496-27-2 7-{(3aR,4S,5R,6aR)-4-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2,2-dimethyl-6-oxo-tetrahydro-cyclopenta[1,3]dioxol-5-yl}-heptanoic acid methyl ester 
• 161978-56-9 methyl 7-(3-tert-butyldimethylsilyloxy-5-oxo-1-cyclopentenyl)heptanoate 
• 84019-04-5 1-(phenylsulfinyl)oct-2-ene 
• 83344-05-2 (12E,14E)-11-(tert-Butyl-dimethyl-silanyloxy)-icosa-12,14-dien-8-ynoic acid 
• 81550-65-4 (12E,14E)-11-(tert-Butyl-dimethyl-silanyloxy)-icosa-12,14-dien-8-ynal 

Relevant academic research and scientific papers

Total synthesis of E1 and E2 isoprostanes by diastereoselective protonation

A short total synthesis of the E-type isoprostanes has been achieved using a two-component coupling process combined with a diastereoselective protonation under reagent control. Mild cleavage of the silyl protective groups with cat. BiBr3 or HF/Py followed by enzymatic hydrolysis of the methyl ester afforded the free E-type isoprostanes.

Synthesis of PGE1 and Various 10α-Hydroxyprostaglandins

Methods for the selective deprotection and/or reduction of compounds of type 2 to provide (7E)-7,8-didehydro-10α-hydroxy-PGE1, (7E)-7,8-didehydro-10α-hydroxy-PGF1, 10α-hydroxy-PGE1, 10α-hydroxy-PGF1, PGE1, and 15-epi-PGE1 as their racemic methyl esters have been examined.