39779-34-5Relevant academic research and scientific papers
Competition and co-operation between ortho directing groups and activating agents: Regioselective metallations of 1-(methoxyphenyl)pyrroles
Faigl, Ferenc,Fogassy, Katalin,Thurner, Angelika,Toke, Laszlo
, p. 4883 - 4888 (1997)
The role of di- and tri-dentate tertiary amine type ligands was studied in regioselective lithiation reactions of 1-(methoxyphenyl)pyrroles with butyllithium (LIC). Clean α-metallation of the pyrrole ring occurred when N,N,N',N',N''-pentamethyldiethylenet
Palladium-catalyzed decarboxylative cross-coupling reaction between heteroaromatic Carboxylic acids and Aryl halides
Bilodeau, Francois,Brochu, Marie-Christine,Guimond, Nicolas,Thesen, Kris H.,Forgione, Pat
experimental part, p. 1550 - 1560 (2010/06/12)
"Chemical Equation Presented" A full overview of the decarboxylative cross-coupling reaction between heteroaromatic carboxylic acids and aryl halides is described. This transformation employs palladium catalysts with short reaction times providing facile synthesis of aryl-substituted heteroaromatics. The effect of each reaction parameter including solvent, base, and additive employed as well as the full substrate scope of this transformation are reported. Mechanistic evidence is also disclosed that sheds light on possible reaction pathways.
Solvent and ligand effects on selective mono- and dilithiation of 1-(chlorophenyl)pyrroles and 1-(methoxyphenyl)pyrroles
Fogassy, Katalin,Kovacs, Krisztina,Keseru, Gyoergy M.,Toke, Laszlo,Faigl, Ferenc
, p. 1039 - 1043 (2007/10/03)
Novel methods for site-selective lithiation of 1-(chlorophenyl)pyrroles and 1-(methoxyphenyl)pyrroles are described. Mono- or dilithiations are governed by change of both the temperature and the solvent from tetrahydrofuran to diethyl ether. Regioselectiv
