397843-09-3

Basic information

• Product Name: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-, dimethyl ester
• CAS NO: 397843-09-3
• Molecular Formula: C17H14Cl2O6
• Molecular Weight: 385.201
• Mol File: 397843-09-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-, dimethyl ester(397843-09-3)
• EPA Substance Registry System: Benzoic acid, 3,3'-methylenebis[5-chloro-6-hydroxy-, dimethyl ester(397843-09-3)

Safety Data

• Hazardous Substances Data: 397843-09-3(Hazardous Substances Data)

Upstream product

• 128626-47-1 3,3'-dichloro-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 50-00-0 formaldehyd 
• 52159-67-8 methyl 3-chloro-2-hydroxybenzoate 

Downstream Products

• 128626-47-1 3,3'-dichloro-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane 
• 154023-64-0 3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dimethoxydiphenylmethane 
• 397843-12-8 24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane 
• 397843-11-7 di[4-acetoxy-3-chloro-5-(methoxycarbonyl)phenyl]ketone 
• 397843-10-6 4,4'-diacetoxy-3,3'-dicarbomethoxy-5,5'-dichlorodiphenylmethane 

Relevant articles and documents

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

The alkenyldiarylmethanes (ADAMs) are currently being investigated as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS. During the course of these studies, a number of ADAM analog

Synthesis and anti-HIV activity of a bile acid analog of cosalane

Cosalane is a novel anti-HIV agent that inhibits the attachment of gp120 to CD4. The therapeutic potential of cosalane is limited by poor oral absorption. In an attempt to target the ileal bile acid transporter and thus facilitate oral bioavailability, a cosalane analog was synthesized in which the disalicylmethane pharmacophore is attached to a bile acid through a linker chain appended to C-17 of the steroid nucleus. The resulting bile acid analog of cosalane retained antiviral activity vs. HIV-1IIIB and HIV-2ROD in MT-4 cells, but was less potent than cosalane.