52159-67-8

Basic information

• Product Name: methyl 3-chlorosalicylate
• Synonyms: methyl 3-chlorosalicylate;3-Chloro-2-hydroxybenzoic acid methyl ester;Einecs 257-694-5
• CAS NO: 52159-67-8
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59238
• EINECS: 257-694-5
• Mol File: 52159-67-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 29-32 °C
• Boiling Point: 238.4 °C at 760 mmHg
• Flash Point: 98 °C
• Appearance: /
• Density: 1.354 g/cm³
• Vapor Pressure: 0.0276mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.28±0.10(Predicted)
• CAS DataBase Reference: methyl 3-chlorosalicylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-chlorosalicylate(52159-67-8)
• EPA Substance Registry System: methyl 3-chlorosalicylate(52159-67-8)

Safety Data

• Hazardous Substances Data: 52159-67-8(Hazardous Substances Data)

Usage

General Description

Methyl 3-chlorosalicylate is a chemical compound with the molecular formula C8H7ClO3. It belongs to the salicylates group of chemicals that are often used in the production of pharmaceuticals and full-scale cosmetic products. This organic compound has a variety of uses, primarily due to its anti-inflammatory, analgesic, and bacteriostatic properties. Its main applications are in the manufacturing processes of antiseptic solutions, perfumes, and flavoring substances. It is known for its mint-like scent, which contributes to its use in cosmetic products as well. The synthesis of methyl 3-chlorosalicylate typically involves the chlorination of salicylic acid followed by methylation. All handling and use of this compound should follow appropriate safety guidelines due to its potential for causing skin and eye irritation.

InChI:InChI=1/C8H7ClO3/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4,10H,1H3

Upstream product

• 1021178-39-1 4-chloro-1-methoxy-1,3-bis-(trimethylsilyloxy)buta-1,3-diene 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 69-72-7 salicylic acid 
• 95-57-8 2-monochlorophenol 
• 67-56-1 methanol 
• 116025-20-8 3-chloro-2-hydroxy-thiobenzoic acid S-methyl ester 
• 76-06-2 chloropicrin 
• 119-36-8 methyl salicylate 
• 1829-32-9 3-Chloro-2-hydroxybenzoic acid 

Downstream Products

• 29956-84-1 3-chloro-2-hydroxybenzamide 
• 3260-94-4 7-chloro-3-benzofuranone 
• 4068-72-8 Methyl-2-hydroxy-3-chlor-5-bromo-benzoat 

Relevant articles and documents

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

The first 4-chloro-1,3-bis(trimethylsilyloxy)-1,3-diene and its application to the regioselective synthesis of chlorinated arenes

Chlorinated phenols, benzophenones, and butenolides are prepared by various one-pot cyclization reactions of the first 4-chloro-1,3-bis(trimethylsilyloxy)-1,3-butadiene.

Dual Fluorescence and Ground State Equilibria in Methyl Salicylate, Methyl 3-Chlorosalicylate, and Methyl 3-tert-Butylsalicylate

Fluorescence spectra of methyl 3-chlorosalicylate, methyl 3-tert-butylsalicylate, and o-hydroxyacetophenone in cyclohexane and ethanol at room temperature have been measured, together with the corrected dual fluorescence excitation spectra of gas-phase methyl salicylate.Based on these observations a ground state equilibrium between two tautomers is proposed, both having an intramolecular hydrogen bond.This model is consistent with a number of methyl salicylate H-bond energy estimates.It also allowed an interpretation of the multiple fluorescence emitted from these and related compounds either in solution or in gas phase.