397843-58-2

Basic information

• Product Name: Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI)
• Synonyms: Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI);[3-(morpholin-4-ylmethyl)phenyl]boronic acid(SALTDATA: HCl);[3-(morpholin-4-ylmethyl)phenyl]boronic acid HCl;[3-(Morpholin-4-ylMethyl)phenyl]boronic acid;[3-(Morpholin-4-ylmethyl)phenyl]boronic acid hydrochloride;[3-(4-MorpholinylMethyl)Phenyl]-Boronic Acid;B-[3-(4-morpholinylmethyl)phenyl]Boronic acid
• CAS NO: 397843-58-2
• Molecular Formula: C₁₁H₁₆BNO₃
• Molecular Weight: 221.06064
• Product Categories: BORONICACID;Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 397843-58-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 394.611 °C at 760 mmHg
• Flash Point: 192.454 °C
• Appearance: /
• Density: 1.208 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI)(397843-58-2)
• EPA Substance Registry System: Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI)(397843-58-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 397843-58-2(Hazardous Substances Data)

Usage

General Description

Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI) is a chemical compound notable for its specific structure and unique properties. It falls under the class of boronic acids, which are compounds featuring a boron atom bonded to an oxygen atom and two hydrocarbon groups. The structure of this chemical also includes a morpholine ring, which is an organic compound characterized by a six-member ring containing four carbon atoms, one oxygen atom and one nitrogen atom. Furthermore, it contains a phenyl group, which is a functional group made of six carbon atoms attached in a cyclic manner, often used in organic chemistry. This chemical therefore has potential uses in various scientific and industrial applications, but its exact uses and properties may vary widely depending on other factors such as its purity, concentration, and the presence of any other substances or conditions.

InChI:InChI=1/C11H16BNO3/c14-12(15)11-3-1-2-10(8-11)9-13-4-6-16-7-5-13/h1-3,8,14-15H,4-7,9H2

Upstream product

• 1025113-70-5 potassium 3-(morpholinomethyl)-phenyltrifluoroborate 
• 110-91-8 morpholine 
• 51323-43-4 (3-(bromomethyl)phenyl)boronic acid 

Downstream Products

• 1617499-05-4 3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-5-[3-(morpholinomethyl)phenyl]pyridin-2-amine 
• 1617499-00-9 3-(1-isopropyltriazol-4-yl)-5-[3-(morpholinomethyl)phenyl]pyridin-2-amine 
• 1239441-34-9 C₂₀H₂₀N₆O 

Relevant articles and documents

Efficient hydrolysis of organotrifluoroborates via silica gel and water

(Chemical Equation Presented) A general, mild, and efficient method for the hydrolysis of organotrifluoroborates to unveil boronic acids using silica gel and H2O was developed. This method proved to be tolerant of a broad range of aryl-, heteroaryl-, alkenyl-, and alkyltrifluoroborates as well as structurally diverse aminomethylated organotrifluoroborates.As anticipated, electron-rich substrates provided the corresponding boronic acids more readily than electron-poor substrates, owing to the resonance-stabilized difluoroborane intermediate. The method developed was expanded further for the conversion of organotrifluoroborates to the corresponding boronate esters. 2009 American Chemical Society.

Preparation and uses of conjugated solid supports for boronic acids

The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.