397883-62-4

Upstream product

• 326473-16-9 (1R)-2-dimethylcarbamoyl-3-(4-hydroxyphenyl)-cyclopropanecarboxylic acid 
• 397883-54-4 (1R)-2-(4-tert-butoxyphenyl)-3-hydroxymethylcyclopropanecarboxylic acid dimethyl amide 
• 326473-14-7 (1R)-2-(4-tert-butoxyphenyl)-3-formyl-cyclopropanecarboxylic acid dimethyl amide 
• 326473-12-5 (1R)-6-(4-tert-butoxyphenyl)-3-oxabicyclo[3.1.0]hexan-2-one 
• 326473-11-4 3-(4-tert-butoxyphenyl)-2Z-propenyl diazoacetate 
• 397883-53-3 3-(4-tert-butoxyphenyl)-prop-2-yne-1-ol 
• 326473-10-3 3-(4-tert-butoxyphenyl)-2Z-propen-1-ol 
• 329318-60-7 1-(tert-butoxy)-4-iodobenzene 
• 60876-70-2 4-tert-butoxybromobenzene 
• 108549-23-1 Dibenzyl N,N-diisopropylphosphoramidite 

Downstream Products

• 397883-70-4 (2S,3S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-({(1R,2R,3R)-2-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-3-dimethylcarbamoyl-cyclopropanecarbonyl}-amino)-butyrylamino]-butyrylamino}-3-methyl-pentanoic acid benzyl ester 

Relevant academic research and scientific papers

Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding

Isothermal titration calorimetry and X-ray crystallography have been used to determine the structural and thermodynamic consequences associated with constraining the pTyr residue of the pYEEI ligand for the Src Homology 2 domain of the Src kinase (Src SH2

Use of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide mimics in SH2 antagonists

Novel conformationally constrained phosphotyrosine pseudopeptide derivatives of the tetrapeptide pY-E-E-I were prepared and evaluated as SH2 binding antagonists. (C) 2000 Elsevier Science Ltd.