397886-46-3

Upstream product

• 397886-55-4 2,2-Dimethyl-propionic acid 2-[(2S,4R,6S)-2-(4-methoxy-phenyl)-6-prop-2-ynyl-[1,3]dioxan-4-yl]-ethyl ester 
• 87318-96-5 (4S)-4-((2R)-2-hydroxypent-4-enyl)-2,2-dimethyl-1,3-dioxolane 
• 397886-69-0 2,2-Dimethyl-propionic acid (3R,5S)-5-hydroxy-3-(4-methoxy-benzyloxy)-8-trimethylsilanyl-oct-7-ynyl ester 
• 3282-30-2 pivaloyl chloride 
• 397886-66-7 2,2-Dimethyl-propionic acid (2S,4R)-2-methanesulfonyloxy-4-(4-methoxy-benzyloxy)-hept-6-enyl ester 
• 397886-54-3 2,2-Dimethyl-propionic acid (3R,5S)-5-hydroxy-3-(4-methoxy-benzyloxy)-oct-7-ynyl ester 
• 397886-50-9 2,2-Dimethyl-propionic acid (2S,4R)-2-hydroxy-4-(4-methoxy-benzyloxy)-hept-6-enyl ester 
• 397886-52-1 2,2-Dimethyl-propionic acid (R)-3-(4-methoxy-benzyloxy)-4-(R)-oxiranyl-butyl ester 
• 397886-48-5 (S)-4-[(R)-2-(4-Methoxy-benzyloxy)-pent-4-enyl]-2,2-dimethyl-[1,3]dioxolane 
• 397886-51-0 (R)-2-[(R)-2-(4-Methoxy-benzyloxy)-pent-4-enyl]-oxirane 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 397886-62-3 2,2-Dimethyl-propionic acid 2-[(2S,4R,6S)-6-[(2E,9E)-(6R,7R)-11-hydroxy-6-(4-methoxy-benzyloxy)-7-methyl-undeca-2,9-dien-4-ynyl]-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-ethyl ester 

Relevant academic research and scientific papers

Synthetic studies aimed at (-)-cochleamycin A. Evaluation of late-stage macrocyclization alternatives

An efficient route to the fully functionalized ABC ring systems of the unnatural enantiomer of cochleamycin A was developed. L-(-)-Malic and L-(-)-ascorbic acids served well as starting materials for the two building blocks used to construct an (E,Z,E)-1,

Studies aimed at the total synthesis of the antitumor antibiotic cochleamycin A. An enantioselective biosynthesis-based pathway to the AB bicyclic core

Chemical equation presented A convergent, highly enantioselective synthesis of the fully functionalized AB sector of cochleamycin A is described. A pair of building blocks, crafted from L-malic and L-ascorbic acids, are conjoined in a manner that gives ri