398133-35-2

Upstream product

• 26661-13-2 4-N-benzoylcytosine 
• 398133-34-1 (1S/R,2S,4R)-1-O-aceyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranoside 
• 398133-31-8 (2R,4R)-4-Acetylsulfanyl-5-(tert-butyl-diphenyl-silanyloxy)-2-fluoro-pentanoic acid methyl ester 
• 398133-30-7 (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-iodo-pentanoic acid methyl ester 
• 479035-91-1 (2R,4R/S)-4-acetylsulfanyl-5-tert-butyldiphenylsilyloxy-2-fluoropentanoic acid methyl ester 
• 479035-90-0 (2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester 
• 398133-33-0 (2S,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-2-phenylselenyl-γ-thiobutyrolactone 
• 398133-32-9 (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone 
• 398133-29-4 (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone 
• 212954-52-4 (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one 

Downstream Products

• 398133-36-3 (+)-N⁴-benzoyl-1-[(1S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-L-ribofuranosyl]cytosine 

Relevant academic research and scientific papers

Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2′,3′-didehydro-2′,3′-dideoxy-2 ′-fluoro-4′-thionucleosides

β-L-2′,3′-Didehydro-2′,3′-dideoxy-2 ′-fluoro-4′-thionucleosides β-L-2′-F-4′-S-d4Ns) have been synthesized and evaluated against HIV-1 in primary human lymphocytes. The key intermediate 8, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1 in

Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.

[reaction: see text] L-2'-Fluoro-4'-thio-2',3'-unsaturated cytidine 11 was synthesized from (R)-2-fluorobutenolide 2, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1. The synthesized compound 11 shows potent antiviral activity against HIV-