398137-19-4

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI) is used as an active pharmaceutical ingredient for the development of anthelmintics and antipsychotics. Its tetrahydro-2H-pyran-4-yl substituent may enhance the compound's efficacy and selectivity in treating parasitic infections and mental health disorders.
Used in Drug Design and Optimization:
The tetrahydro-2H-pyran-4-yl substituent in Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI) can be utilized in drug design and optimization processes to improve the pharmacokinetic and pharmacodynamic properties of piperazine-based drugs. This may lead to the development of more effective and safer therapeutic agents.
Used in Research and Development:
Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI) serves as a valuable research tool for studying the structure-activity relationships of piperazine compounds. It can be used to investigate the impact of different substituents on the biological activity and therapeutic potential of piperazine-based drugs.
Used in Drug Synthesis:
Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI) can be employed as a key intermediate in the synthesis of more complex piperazine derivatives with potential applications in various therapeutic areas. Its unique tetrahydro-2H-pyran-4-yl substituent may facilitate the development of novel drug candidates with improved properties.

Upstream product

• 706759-32-2 4-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 1033594-04-5 1-benzyl-4-(tetrahydro-2H-pyran-4-yl)piperazine 

Downstream Products

• 871828-53-4 4-(tetrahydro-pyran-4-yl)-piperazine-1-carbothioic acid amide 
• 1026501-11-0 4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid 
• 288252-36-8 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-1-yl)piperazin-1-yl]benzonitrile 
• 866086-06-8 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-(4-hydroxy-3,5-dimethyl-benzyl)-2-oxo-2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-ethyl ester 
• 910575-73-4 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-(4-benzyloxy-3-chloro-5-methyl-benzyl)-2-oxo-2-[4-(tetrahydropyran-4-yl)-piperazin-1-yl]-ethyl ester 
• 1374567-07-3 C₂₆H₃₀ClN₅O₃ 
• 1374567-08-4 C₂₇H₃₀F₃N₅O₄ 
• 1450723-72-4 C₁₆H₂₅N₃O₃S 
• 1450724-30-7 C₂₃H₂₈N₄O₇S 
• 1450723-50-8 N-[[4-(4-tetrahydropyran-4-ylpiperazin-1-yl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450723-78-0 C₁₆H₂₁N₃O₃S 

Relevant academic research and scientific papers

THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

TRIAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST ACETYL-COA CARBOXYLASE

The present invention relates to a novel triazine derivative or a pharmaceutically acceptable salt thereof, and an Acetyl-CoA Carboxylase (ACC) comprising same as an active ingredient. The triazine derivative of the present invention effectively inhibits the activity of ACC and it may be used for preventing or treating obesity, diabetes, dyslipidemia and diseases related to metabolic syndrome.

NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES

The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.

1-Alkyl-4-acylpiperazines as a new class of imidazole-free histamine H 3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H3 receptor. The most potent amides had antagonist potencies in the subnanomolar range.

Fused bicyclic amide compounds and medicinal use thereof

The present invention provides a compound represented by the formula (I) wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R1, R2 and R3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.