398152-56-2Relevant academic research and scientific papers
New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics
Hauck, Sheila I.,Cederberg, Christer,Doucette, Amanda,Grosser, Lena,Hales, Neil J.,Poon, Grace,Gravestock, Michael B.
, p. 337 - 340 (2007/10/03)
Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl triazol
OXAZOLIDINONE CHEMOTHERAPEUTIC AGENTS
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, (2008/06/13)
Compounds of the formula or therapeutically acceptable salts or prodrugs thereof, are useful for treating bacterial infections, psoriasis, arthritis, and toxicity due to chemotherapy. Preparation of the compounds, compositions containing the compounds, an
Oxazolidinone chemotherapeutic agents
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, (2008/06/13)
Compounds of the formula or therapeutically acceptable salts or prodrugs thereof, are useful for treating bacterial infections, psoriasis, arthritis, and toxicity due to chemotherapy. Preparation of the compounds, compositions containing the compounds, an
Carbon-carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria.
Lee,Allwine,Barbachyn,Grega,Dolak,Ford,Jensen,Seest,Hamel,Schaadt,Stapert,Yagi,Zurenko,Genin
, p. 3243 - 3253 (2007/10/03)
In an effort to expand the spectrum of activity of the oxazolidinone class of antibacterial agents to include Gram-negative bacteria, a series of new carbon-carbon linked pyrazolylphenyl analogues has been prepared. The alpha-N-substituted methyl pyrazole
