398152-55-1

Upstream product

• 149524-45-8 (S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 398152-57-3 N-[((5S)-3-{4-[(E)-3-(dimethylamino)-2-propenoyl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide 
• 398152-58-4 N-{3-[3-fluoro-4-(2H-pyrazol-3-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 398152-56-2 N-{[(5S)-3-(4-ethynyl-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide 
• 139071-99-1 (S)-N-<<3-(4-acetyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl>methyl>acetamide 

Relevant academic research and scientific papers

New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics

Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl triazol

Carbon-carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria.

In an effort to expand the spectrum of activity of the oxazolidinone class of antibacterial agents to include Gram-negative bacteria, a series of new carbon-carbon linked pyrazolylphenyl analogues has been prepared. The alpha-N-substituted methyl pyrazole