39823-98-8

Upstream product

• 100-39-0 benzyl bromide 
• 5336-08-3 D-Ribono-1,4-lactone 
• 20603-45-6 3,4-O-Benzylidene-D-(+)-ribonic acid δ-lactone 
• 152711-08-5 2-O-benzyl-3,4-O-(R)-benzylidene-δ-D-ribonolactone 

Downstream Products

• 152711-16-5 (S)-3-hydroxy-5-hydroxymethyl-2(5H)-furanone 
• 152711-17-6 (S)-3-benzyloxy-5-hydroxymethyl-2(5H)-furanone 
• 19473-20-2 (3S,5S)-(+)-3-hydroxy-5-hydroxymethyl-tetrahydrofuran-2-one 
• 152711-18-7 (S)-3-benzyloxy-5-p-toluenesulfonyloxymethyl-2(5H)-furanone 
• 82130-87-8 (S)-3-p-toluenesulfonyloxy-5-hydroxymethyl-2(5H)-furanone 

Relevant academic research and scientific papers

Clarifying the use of benzylidene protecting group for d-(+)-ribono-1,4-lactone, an essential building block in the synthesis of c-nucleosides

In the last two years, nucleosides analogues, a class of well-established bioactive com-pounds, have been the subject of renewed interest from the scientific community thanks to their antiviral activity. The COVID-19 global pandemic, indeed, spread light

A two step synthesis of 3-deoxy-D- or L-glycono-1,4-lactones and 2-O-alkyl-3-deoxy-D-glycono- 1,4-lactones from D- or L-glyconolactones

Treatment of unprotected D- or L-glyconolactones with sodium hydride and alkyl halides, in dimethylsulfoxide, led to the corresponding 2-O-alkyl-3-deoxy-2-enono-1,4-lactones. Hydrogenolysis of 2-O-benzyl derivatives by catalytic hydrogen transfer with pal

Synthetic approaches to either homochiral or achiral derivatives of 3-hydroxy-2(5H)-furanone (isotetronic acid)

Several title compounds were synthesized according to new methods based either on the use of D-ribonolactone as a chiral precursor or on the cyclization of 2,4-dioxopentanoic acid as a suitable achiral precursor. Base-induced elimination and subsequent acid-promoted ring contraction is an efficient protocol for the preparation of isotetronic acids from 2-O-alkyl-3,4-O-benzylidene-D-ribono-1,5-lactone derivatives.