3984-18-7

Basic information

• Product Name: Sulfamide, cyclohexyl- (7CI,8CI,9CI)
• Synonyms: Sulfamide, cyclohexyl- (7CI,8CI,9CI);N-cyclohexylSulfamide
• CAS NO: 3984-18-7
• Molecular Formula: C₆H₁₄N₂O₂S
• Molecular Weight: 178.25256
• Product Categories: SULFONAMIDE
• Mol File: 3984-18-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Sulfamide, cyclohexyl- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamide, cyclohexyl- (7CI,8CI,9CI)(3984-18-7)
• EPA Substance Registry System: Sulfamide, cyclohexyl- (7CI,8CI,9CI)(3984-18-7)

Safety Data

• Hazardous Substances Data: 3984-18-7(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 147715-84-2 tert-butyl (1-cyclohexyl)aminosulfonylcarbamate 

Downstream Products

• 63845-68-1 C₉H₁₉N₃O₂S 
• 3488-39-9 N-n-Butyl-N'-cyclohexylsulfamide 
• 63845-61-4 C₁₃H₂₈N₄O₄S₂ 
• 1612186-14-7 C₉H₁₈N₂O₄S 
• 1054463-13-6 C₁₃H₂₄N₄O₃S 
• 1054463-11-4 C₁₁H₂₀N₄O₃S 
• 936756-45-5 2-cyclohexyl-3-methyl-1,1-dioxo-1,2-dihydro-1^λ6-1,2,6-thiadiazine-5-carboxylic acid ethyl ester 
• 936756-37-5 3-(4-bromophenyl)-2-cyclohexyl-1,1-dioxo-1,2-dihydro-1^λ6-1,2,6-thiadiazine-5-carboxylic acid ethyl ester 
• 106350-04-3 2-Cyclohexyl-1,1-dioxo-1λ⁶-[1,2,6]thiadiazinane-3,5-dione 
• 75420-75-6 N-Benzyl-N'-cyclohexylsulfamide 
• 122172-62-7 3,4-Diamino-2-cyclohexyl-1,1-dioxo-1H-1λ⁶-[1,2,5]thiadiazol-2-ium; chloride 
• 85515-63-5 C₁₂H₂₆N₂O₂S 
• 85515-64-6 C₁₄H₃₀N₂O₂S 
• 85515-65-7 C₁₁H₂₄N₂O₂S 

Relevant articles and documents

Convenient Synthesis of Novel N -Acylsulfonamides Containing Phosphonate Moiety

The present study describes a convenient method for the synthesis of new N-acylsulfonamides containing phosphonate moiety. The N-acylsulfonamides were prepared starting from chlorosulfonyl isocyanate (CSI) in four steps (carbamoylation, sulfamoylation, deprotection, and acylation). Trimethylphosphite has been used to introduce the phosphonate moiety into N-acylsulfonamides via Arbuzov reaction. GRAPHICAL ABSTRACT

Synthesis and antibacterial activity of sulfonamides. SAR and DFT studies

A series of substituted sulfonamide derivatives were synthesized from chlorosulfonyl isocyanate (CSI) in tree steps (carbamoylation, sulfamoylation and deprotection). Antibacterial activity in vitro of some newly formed compounds investigated against clinical strains Gram-positive and Gram-negative: Escherichia coli and Staphylococcus aureus applying the method of dilution and minimal inhibition concentration (MIC) methods. These compounds have significant bacteriostatic activity with totalities of bacterial strains used. DFT calculations with B3LYP/6-31G(d) level have been used to analyze the electronic and geometric characteristics deduced for the stable structure of three compounds presenting conjugation between a nitrogen atom N through its lone pair and an aromatic ring next to it. The principal quantum chemical descriptors have been correlated with the antibacterial activity.

Macrocyclic compounds as inhibitors of viral replication

The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.