398474-02-7Relevant academic research and scientific papers
Aplysamine-1 and related analogs as histamine H3 receptor antagonists
Swanson, Devin M.,Wilson, Sandy J.,Boggs, Jamin D.,Xiao, Wei,Apodaca, Richard,Barbier, Ann J.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 897 - 900 (2007/10/03)
Aplysamine-1 (1), a marine natural product, was synthesized and screened for in vitro activity at the human and rat histamine H3 receptors. Aplysamine-1 (1) was found to possess a high binding affinity for the human H3 receptor (Ki = 30 ± 4 nM). Synthetic analogs of 1, including des-bromoaplysamine-1 (10) and dimethyl-{2-[4-(3-piperidin-1-yl- propoxy)-phenyl]-ethyl}-amine (13), were potent H3 antagonists.
A new class of diamine-based human histamine H3 receptor antagonists: 4-(Aminoalkoxy)benzylamines
Apodaca, Richard,Dvorak, Curt A.,Xiao, Wei,Barbier, Ann J.,Boggs, Jamin D.,Wilson, Sandy J.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 3938 - 3944 (2007/10/03)
4-(Aminoalkoxy)benzylamines were prepared and screened for in vitro activity at the human histamine H3 receptor. Some members of this series exhibited subnanomolar binding affinities. Analogues in which one nitrogen atom was replaced with a met
