398487-31-5Relevant academic research and scientific papers
IMINO SULFANONE INHIBITORS OF ENPP1
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Paragraph 0152; 0154; 0155, (2021/11/13)
The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to sulfoximine- based inhibitors of ENPP1 of Formula (I) and methods of their use for treating disease mediated by ENPP1.
Preparation method of 4-chlorine-7-methoxy quinoline-6-amide
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, (2020/12/31)
The invention relates to a preparation method of 4-chlorine-7-methoxy quinoline-6-amide, which comprises the following steps of by using 2-amino-4-methoxy-5-cyanobenzoic acid and acetaldehyde as raw materials, carrying out cyclization reaction, chlorination reaction and hydrolysis reaction to efficiently synthesize the 4-chlorine-7-methoxy quinoline-6-amide. The preparation method of the 4-chlorine-7-methoxy quinoline-6-amide provided by the invention is a preparation method which is high in yield, low in cost, good in product purity and suitable for industrialization.
Preparation method of lenvatinib
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, (2020/05/01)
The invention discloses a preparation method of lenvatinib, which comprises the following steps: by using 4-nitro-2-chlorobenzonitrile as an initial raw material, introducing nitro into molecules forelectron withdrawing, thereby greatly lowering the elect
A [...] synthetic method
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Paragraph 0043; 0048; 0053; 0057; 0062; 0066, (2019/05/22)
The invention provides a method of synthesizing [...]. First of all the invention to 4 - cyano - 3 - hydroxy aniline as the starting material, by dimethyl carbonate methylation, after third acid in the oximation reaction at room temperature, the conditions in the PPA shut-ring forms the 6 - cyano - 7 - methoxy - 4 - quinolinone, in thionyl chloride formed under the action of the 6 - cyano - 7 - methoxy - 4 - [...], under acidic conditions [...] cyano hydrolysis synthesis of one of the intermediates 6 - formamido - 7 - methoxy - 4 - chloroquinolin. Then the 4 - hydroxy - 2 chloroaniline with cyanogen bromide at low temperature 4 - hydroxy - 2 - chloro cyaniding amine, the 4 - hydroxy - 2 - chloro cyaniding amine with bearing-displacement generating Reeth reaction synthesis [...] another key intermediate 1 - (2 - chloro - 4 - hydroxy-phenyl) - 3 - ring propyl urea. Finally the two intermediate 6 - formamido - 7 - methoxy - 4 - chloroquinolin and 1 - (2 - chloro - 4 - hydroxy-phenyl) - 3 - ring propyl urea in the alkaline environment for carrying out the alkylation reaction [...]. This scheme has mild reaction conditions, no highly toxic reagent, environmental protection and the like.
QUINOLINE DERIVATIVES
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Page/Page column 109, (2008/06/13)
The invention concerns quinoline derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
QUINOLINE DERIVATIVES
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Page/Page column 81-82, (2008/06/13)
The invention concerns quinoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.
