398489-51-5Relevant articles and documents
THERAPEUTIC COMPOUNDS AND COMPOSITIONS AND THEIR USE AS PKM2 MODULATORS
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Page/Page column 69; 70, (2014/05/24)
Compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
Cobalt-catalyzed coupling of alkyl iodides with alkenes: Deprotonation of hydridocobalt enables turnover
Weiss, Matthias E.,Kreis, Lukas M.,Lauber, Alex,Carreira, Erick M.
supporting information; experimental part, p. 11125 - 11128 (2012/02/02)
Completing the cycle: Cobalt complexes I and II were found to catalyze intramolecular alkyl Heck-type coupling reactions of alkyl iodides to alkenes upon irradiation with visible light in the presence of a tertiary amine base. The use of base is key to the catalytic turnover. The compatibility of the method with a broad range of functional groups opens opportunities for synthesis. Copyright