398490-81-8

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 398490-79-4 4-Methyl-benzenesulfinic acid [2-indan-2-yl-eth-(E)-ylidene]-amide 
• 5804-85-3 diethylaluminium cyanide 
• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 
• 188447-91-8 (S)-p-toluenesulfinimide 
• 146737-67-9 (indan-2-yl)acetaldehyde 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure ethylenediamines from chiral sulfinimines: A new twist to the Strecker reaction

Addition of various cyanide nucleophiles on chiral t-butylsulfinimine and p-tolylsulfinimine derivatives are described and demonstrated that aliphatic t-butylsulfinimines are excellent substrates for a new variant of the Strecker reaction where cyanide ions are delivered through ethylisopropoxyaluminum cyanide or trimethylsilylcyanide combined with a Lewis acid catalyst. The reaction proceeds with high yield and high diastereoselectivity, which can be further improved by additional crystallizations.