398516-85-3

Upstream product

• 632357-77-8 2,2-Dimethyl-propionic acid 2-[(2S,3S,4R,6S)-6-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3-vinyl-tetrahydro-pyran-2-yl]-ethyl ester 
• 112348-04-6 ethyl (S)-4-benzyloxy-3-hydroxybutanoate 
• 223769-07-1 (3S)-4-(benzyloxy)-3-hydroxy-N-methoxy-N-methylbutanamide 
• 398516-72-8 (S)-6-Benzyloxy-5-hydroxy-2-methyl-hex-1-en-3-one 
• 632357-74-5 (2S,4R)-1-Benzyloxy-5-methyl-hex-5-ene-2,4-diol 
• 398516-79-5 (E)-3-((1S,3R)-1-Benzyloxymethyl-3-hydroxy-4-methyl-pent-4-enyloxy)-acrylic acid ethyl ester 
• 398516-77-3 (2S,4R)-1-Benzyloxy-4-(4-methoxy-benzyloxy)-5-methyl-hex-5-en-2-ol 
• 398516-80-8 ((4aS,5S,7S,8aR)-7-Benzyloxymethyl-2,2,4a-trimethyl-hexahydro-1,6-dioxa-2-sila-naphthalen-5-yl)-acetic acid ethyl ester 
• 398516-81-9 2,2-Dimethyl-propionic acid 2-[(2S,3R,4R,6S)-6-benzyloxymethyl-4-hydroxy-3-(2-hydroxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-ethyl ester 
• 632357-75-6 2,2-Dimethyl-propionic acid 2-((4aS,5S,7S,8aR)-7-benzyloxymethyl-2,2,4a-trimethyl-hexahydro-1,6-dioxa-2-sila-naphthalen-5-yl)-ethyl ester 
• 398516-83-1 2,2-Dimethyl-propionic acid 2-[(2S,3S,4R,6S)-6-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-ethyl ester 
• 632357-76-7 2,2-dimethyl-propionic acid 2-{6-benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-tetrahydro-pyran-2-yl}-ethyl ester 

Downstream Products

• 632357-43-8 2,2-Dimethyl-propionic acid 2-((4aS,5S,7S,8aR)-7-benzyloxymethyl-2,2,4a-trimethyl-tetrahydro-pyrano[4,3-d][1,3]dioxin-5-yl)-ethyl ester 
• 398516-88-6 2,2-Dimethyl-propionic acid 2-{(4aS,5S,7S,8aR)-7-[(E)-4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-2,2,4a-trimethyl-tetrahydro-pyrano[4,3-d][1,3]dioxin-5-yl}-ethyl ester 
• 632357-97-2 2,2-Dimethyl-propionic acid 2-{(4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-[(E)-4-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-but-1-enyl]-tetrahydro-pyrano[4,3-d][1,3]dioxin-5-yl}-ethyl ester 
• 632357-60-9 2,2-Dimethyl-propionic acid 2-{(4aS,5S,7S,8aR)-2,2,4a-trimethyl-7-[(E)-4-(1-phenyl-1H-tetrazole-5-sulfonyl)-but-1-enyl]-tetrahydro-pyrano[4,3-d][1,3]dioxin-5-yl}-ethyl ester 
• 632357-73-4 2,2-Dimethyl-propionic acid 2-((2S,3R,4R,6S)-6-benzyloxymethyl-4-hydroxy-3-hydroxymethyl-3-methyl-tetrahydro-pyran-2-yl)-ethyl ester 

Relevant academic research and scientific papers

Lasonolide A: Structural revision and total synthesis

The proposed structure of lasonolide A was synthesized employing radical cyclization reactions of β-alkoxyacrylates for preparation of the tetrahydropyranyl units A and B, but the spectroscopic data did not match those of the natural product. Both enantio

Lasonolide A: Structural revision and synthesis of the unnatural (-)-enantiomer

Total synthesis of the unnatural (-)-enantiomer of lasonolide A was achieved starting from ethyl l-malate. The two tetrahydropyranyl fragments were prepared stereoselectively via radical cyclization reactions of β-alkoxyacrylates. The full structure of na