39853-58-2

Usage

InChI:InChI=1/C14H15NOS/c1-14(2)7-10-13(11(16)8-14)17-12-6-4-3-5-9(12)15-10/h3-6,15H,7-8H2,1-2H3

Upstream product

• 39853-68-4 2,2,10-trimethyl-2,3-dihydro-1H,10H-phenothiazin-4-one oxime 
• 126-81-8 dimedone 
• 137-07-5 2-amino-benzenethiol 
• 109363-86-2 2,3-dihydro-2,2,5-trimethyl-5H-phenothiazin-4(1H)-one 
• 106513-66-0 C₁₇H₂₁NOS 
• 82195-00-4 5,5-dimethyl-3-(2-methylthiophenylamino)cyclohex-2-en-1-one 
• 62-53-3 aniline 
• 68890-20-0 3-((2-bromophenyl)-amino)-6,6-dimethylcyclohex-2-enone 
• 85239-67-4 3-((2-iodophenyl)amino)-5,5-dimethylcyclohex-2-enone 
• 95-16-9 1,3-Benzothiazole 
• 39853-64-0 2,2,10-trimethyl-2,3-dihydro-1H,10H-phenothiazin-4-one 
• 2987-53-3 2-(Methylthio)aniline 
• 41085-32-9 o-aminophenyl methyl sulfoxide 
• 1195-91-1 2-bromodimedone 

Downstream Products

• 137411-45-1 10-Benzyl-2,3-dihydro-2,2-dimethyl-10H-phenothiazin-4(1H)-one 
• 137411-44-0 4a-Benzyl-2,3-dihydro-2,2-dimethyl-4aH-phenothiazin-4(1H)-one 

Relevant academic research and scientific papers

A facile and rapid method for preparation of thiazine and thiadiazine derivatives by sonication technique

Ultrasound accelerated synthesis of 2,3-(substituted)benzo-1,4-thiazino[5, 6-b]-4H-9H-7- methyl-10-oxoquinolines (4), 7-substituted-2,2-dimethyl-2,3- dihydro-1H,10H-phenothiazin- 4-one (5), 4-substituted-3,9, 10-trihydro-11-oxo- quinolino[2,3-b]-1,3,4-thiadiazino[2,3-d]- 1,2,4-triazole (6), and 7,7-dimethyl-7,8-dihydro-3H,5H,6H-1,2,4-triazolo[3,4-b][1,3,4] benzothiadiazin-9-one (7) from carbostyril and dimedone using sulfur powder and iodine as a catalyst in THF is reported. The structures of the compounds have been elucidated on the basis of spectral and elemental analysis.

FT-IR, FT-Raman and computational study of 1H-2,2-dimethyl-3H-phenothiazin- 4[10H]-one

FT-IR and FT-Raman spectra of 1H-2,2-dimethyl-3H-phenothiazin-4[10H]-one were recorded and analyzed. The vibrational wavenumbers were computed using HF/6-31G(d) and B3LYP/6-31G(d) basis. The data obtained from vibrational wavenumber calculations are used to assign vibrational bands obtained in infrared and Raman spectroscopies of the studied molecule. The first hyperpolarizability, infrared intensities and Raman activities are reported. The calculated first hyperpolarizability is comparable with the reported values of similar derivatives and is an attractive object for future studies of non-linear optics. The geometrical parameters of the title compound are in agreement with XRD crystal structure data. The red shift of the N?H stretching wavenumber in the infrared spectrum from the computed wavenumber indicates the weakening of the N?H bond.

A cleavage reaction of benzothiazole with cyclic 1,3-dicarbonyls in the presence of potassium dihydrogen phosphate

A facile and convenient synthesis of phenothiazine derivatives has been achieved by condensation reaction of benzothiazole derivatives with 1,3-dicarbonyls in the presence of potassium dihydrogen phosphate (KH2PO4) in moderate to good yields under mild conditions.

Synthesis and Electrochemical Study of Benzothiazine and Phenothiazine Derivatives

A number of benzothiazine and phenothiazine derivatives are prepared by reaction of 2-mercaptoaniline and cyclic β-diketo compounds or by reaction of bidentate nucleophiles on 4-chloro-3-nitrocoumarin by using the HSAB principle.The topological resonance energies per ?-electron (TREPE's) are calculated for nine benzothiazine and phenothiazine derivatives and correlated with the first reversible peak potentials.The analysis of the data shows a good correlation between the TREPE values and the oxidation potentials.The chemical behavior of the electrochemically generated radical cations of the two related heterocyclic systems: 6,12-dihydrobenzopyrranobenzothiazin-6-one (1) and 2,3-dihydro-2,2-dimethylphenothiazin-6(1H)-one (2) are examined by using the electroanalytical techniques and preparative controlled potential electrolysis.HMO calculations are used to predict the most reactive sites toward the nucleophilic attack.

Umpolung Strategy for α,α’-Functionalization of Ketones with 2-Aminothiophenols: Stereoselective Access to Spirobis(1,4-benzothiazines)

In the presence of TFA as a strong acid catalyst in DMSO, α,α’-enolizable ketones were found to be stereoselectively α,α’-functionalized with 2-aminothiophenols to provide spirobis(1,4-benzothiazine) derivatives. (Figure presented.).

Graphene oxide (GO): An efficient carbocatalyst for the benign synthesis of functionalized 1,4-benzothiazines

Graphene oxide (GO) has been found to be highly efficient and recyclable carbocatalyst for the benign construction of heterocyclic molecule 1,4-benzothiazine from 2-aminothiophenol and 1,3-dicarbonyl compound. A vast range of highly functionalized 1,4-ben

Radical Route to 1,4-Benzothiazine Derivatives from 2-Aminobenzenethiols and Ketones under Transition-Metal-Free Conditions

Transition-metal-free radical access to 1,4-benzothiazine derivatives from o-aminobenzenethiols is disclosed. This procedure is available for various ketones including α,β-unsaturated, cyclic, linear, and fluoroalkyl ketones to generate a number of 1,4-benzothiazines, which exist in numerous bioactive and natural molecules, rendering this protocol attractive to both synthetic and medicinal chemistry.

The involvement of the trisulfur radical anion in electron-catalyzed sulfur insertion reactions: Facile synthesis of benzothiazine derivatives under transition metal-free conditions

An efficient and practical synthesis of benzothiazine by K2S initiated sulfur insertion reaction with enaminones via electron catalysis is developed. This protocol provides a new, environment-friendly and simple strategy to construct benzothiaz

Synthesis of thiazines using an unusual means-sonication

A trouble free & swift method have been established for synthesis of thiazines from carbostyril CAB1 and dimidone DIM2 using sulphur powder and iodine as a catalyst in presence of THF solvent. The structures of the compounds have been elucidated on the basis of spectral analysis.

Microwave-mediated synthesis of some novel heterocycles containing thiazole, oxazole, thiazine, oxazine, thiadiazine and triazolo-thiadiazine moiety

5,5-Dimethyl cyclohexane-1,3-dione 1 has been brominated to yield 2-bromo-5,5-dimethyl cyclohexane-1,3-dione 2 which on further reaction with substituted thiocarbamides, carbamides, 2-aminothiophenols, 2-aminophenol, thiocarbohydrazones, thiosemicarbazones and triazoles has furnished 2-substituted imino-5,5-dimethyl-2,3,5,6 -tetrahydro-4H-benzothiazol-7-one 3, 2-substituted imino-5,5-dimethyl-2,3,5,6,-tetrahydro-4H-benzoxazol-7-one 4, 7-substituted-2,2-dimethyl-2,3-dihydro-1H,10H -phenothiazin-4-one 5, 2,2-dimethyl-2,3-dihydro-1H,10H-phenoxazin-4-one 6, Schiff base of 2-hydrazino-6,6-dimethyl-6,7-dihydro-4H,5H-benzo[1,3,4]thiadiazin-8-one 7, Schiff base of 2-amino-6,6-dimethyl-6,7-dihydro-4H,5H-benzo[1,3,4] thiadiazin-8-one 8 and 3-substituted alkyl-7,7-dimethyl-7,8-dihydro-5H,6H-1,2,4- triazolo[3,4-b][1,3,4]benzothiadiazin-9-one 9 respectively. All the final compounds have been synthesized by microwave irradiation as well as by conventional method.