68890-20-0Relevant academic research and scientific papers
Palladium-catalyzed coupling of vinylogous amides with aryl halides: Applications to the synthesis of heterocycles
Edmondson, Scott D.,Mastracchio, Anthony,Parmee, Emma R.
, p. 1109 - 1112 (2007/10/03)
Described herein is the first example of the palladium-catalyzed coupling of vinylogous amides with aryl bromides and chlorides. The scope of this reaction with respect to the aryl component is investigated. Additionally, a tandem reaction sequence in which the above coupling is followed by an intramolecular Heck reaction is presented. These reactions can be applied to high-yielding, one-pot syntheses of nitrogen-containing heterocycles.
