3986-03-6

Basic information

• Product Name: 4-Hmclc
• Synonyms: 4-Hmclc;4-(hydroxymethyl)colchicine
• CAS NO: 3986-03-6
• Molecular Formula: C23H27NO7
• Molecular Weight: 429.46298
• Mol File: 3986-03-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 778.1°Cat760mmHg
• Flash Point: 424.4°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 1.74E-25mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 4-Hmclc(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hmclc(3986-03-6)
• EPA Substance Registry System: 4-Hmclc(3986-03-6)

Safety Data

• Hazardous Substances Data: 3986-03-6(Hazardous Substances Data)

Usage

General Description

4-Hmclc, or 4-Hydroxy-3-methoxycinnamaldehyde, is a chemical compound with a molecular formula C10H10O3. It is a derivative of cinnamaldehyde, and is commonly found in plants such as cinnamon. 4-Hmclc has been studied for its potential applications in food, pharmaceuticals, and cosmetics due to its antioxidant, antimicrobial, and anti-inflammatory properties. It has also been investigated for its potential role in the treatment of diabetes and cardiovascular diseases. The compound is known for its sweet, woody aroma and is used as a flavoring agent in the food industry. Additionally, it has been used in traditional medicine for its perceived health benefits. Overall, 4-Hmclc is a versatile compound with potential applications in various industries and fields of research.

InChI:InChI=1/C23H27NO7/c1-12(26)24-17-8-6-14-16(11-25)21(29-3)23(31-5)22(30-4)20(14)13-7-9-19(28-2)18(27)10-15(13)17/h7,9-10,17,25H,6,8,11H2,1-5H3,(H,24,26)/t17-/m0/s1

Upstream product

• 2730-82-7 4-Formylcolchicine 
• 64-86-8 colchicine 
• 50-00-0 formaldehyd 

Relevant articles and documents

New C(4)-functionalized colchicine derivatives by a versatile multicomponent electrophilic aromatic substitution

Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H2SO4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards various tumor cell lines, and their stimulatory effect on the development of polarity in human neutrophils.

4-Chlorocolchicine derivatives bearing a thiourea side chain at the C-7 position as potent anticancer agents

A series of 4-substituted colchicine derivatives were synthesized and evaluated with an eye toward developing new anticancer agents. As a result, 4-chlorocolchicine derivatives bearing a thioureide side chain at the C-7 position were found to exhibit significant cytotoxicities to three human cancer cell lines (A549, HT-29, and HCT116). In particular, compound 26 having an ethylthioureide group at the C-7 had high antitumor activity in vivo and a broad effective dosage range. Furthermore, compound 58, which has a (5-methylpyrazol-3-yl)thioureide group at the C-7 side chain, exhibited strong cytotoxicity and desirable metabolic stability in vitro.