39860-52-1Relevant academic research and scientific papers
A bioluminescent probe for imaging endogenous hydrogen polysulfides in live cells and a murine model of bacterial infection
Li, Jun-Bin,Wang, Qianqian,Liu, Hong-Wen,Yuan, Lin,Zhang, Xiao-Bing
supporting information, p. 4487 - 4490 (2019/04/26)
In this work, we report the first bioluminescent probe BP-PS for detecting H2Sn with high specificity and sensitivity. Owing to the bioluminescence imaging without requiring an excitation light source, tissue autofluorescence is eliminated and BP-PS shows a high signal-to-noise ratio. Moreover, BP-PS was successfully utilized to visualize endogenous H2Sn in live cells and a murine model of bacterial infection.
Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging
Anila, Hoskere A.,Sreedharan, Sreejesh,Ali, Firoj,Smythe, Carl G.,Thomas, Jim A.,Das, Amitava
supporting information, p. 3735 - 3738 (2018/04/16)
A new physiologically benign and cell membrane permeable BODIPY based molecular probe, MB-Sn, specifically senses intracellular hydrogen polysulfides (H2Sn, n > 1) localized in the endoplasmic reticulum. This reagent is su
A one-pot preparation of N-2-mercaptobenzoyl-amino amides
Bahde, Robert J.,Appella, Daniel H.,Trenkle, William C.
supporting information; experimental part, p. 4103 - 4105 (2011/09/19)
The HIV-1 nucleocapsid (NCp7), structurally defined by zinc-binding domains, participates in crucial stages of the HIV-1 lifecycle and is mutationally nonpermissive, making it an attractive anti-HIV target. Mode of action studies have shown that the secondary structure and activity of NCp7 can be disrupted by acyl transfer from N-2-mercaptobenzoyl-amino amides. We have developed an improved one-pot reaction that affords N-2-mercaptobenzoyl-amino acids on multi-gram scales. This synthetic route allows for rapid modular construction and has greatly expanded the scope of easily accessible potential NCp7 inhibitors.
Kinase Inhibitors
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Page/Page column 5-6, (2010/11/25)
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
A new synthesis of 4H-1-benzothiopyran-4-ones using (trimethylsilyl)methylenetriphenylphosphorane
Kumar, Pradeep,Bodas, Mandar S
, p. 9755 - 9758 (2007/10/03)
The reaction of silyl ester of S-acyl(aroyl) thiosalicylic acids 3 with (trimethylsilyl)methylenetriphenylphosphorane 4 in step wise fashion leads to the acylphosphoranes 7, which subsequently undergo intramolecular Wittig cyclization on the thiolester carbonyl to afford the 4H-1-benzothiopyran-4-ones 8 in good to excellent yields.
SYNTHETIC HYDROGEN BONDING RECEPTORS AS MODELS OF TRANSACYLASE ENZYMES
Tecilla, Paolo,Jubian, Vrej,Hamilton, Andrew D.
, p. 435 - 448 (2007/10/02)
A family of synthetic receptors has been prepared containing a barbiturate binding site and an appended thiol nucleophile.These are shown to cause large accelerations in the thiolysis reactions of barbiturate active ester derivatives.The size of the acceleration is shown to depend critically on the length and flexibility of the spacer that links the thiol to the receptor.
An Efficient Approach to the Synthesis of 4H-1-Benzothiopyran-4-ones via Intramolecular Wittig Reaction
Kumar, Pradeep,Rao, Ashok T.,Pandey, Bipin
, p. 1580 - 1581 (2007/10/02)
The reaction of S-acyl(aroyl)thiosalicylic acids 2 with N-phenyl(triphenylphosphoranylidene)ethenimine 3 in stepwise fashion leads to the acylphosphoranes 5 which subsequently undergo intramolecular Wittig cyclization on the thiolester carbonyl to afford
