39861-30-8

Upstream product

• 154-41-6 threo-1-phenyl-1-hydroxy-2-propylammonium chloride 
• 4380-71-6 erythro-2-benzoylamino-1-phenylpropan-1-ol 
• 38222-77-4 trans-2,5-diphenyl-4-methyl-1,3-oxazoline 
• 3198-15-0 (1R,2S)-(-)-norephedrine hydrochloride 
• 154-41-6 erythro-1-phenyl-1-hydroxy-2-propylammonium chloride 
• 38222-78-5 threo-1-benzoyloxy-1-phenyl-2-propylammonium chloride 

Downstream Products

• 3139-67-1 1-Phenyl-1-<4-aethyl-phenyl>-2-amino-propan 
• 802564-55-2 2-(4-methoxy-phenyl)-1-methyl-2-phenyl-ethylamine 
• 3139-55-7 1,1-diphenylisopropylamine 
• 2706-50-5 amphetamine hydrochloride 
• 78373-96-3 cis-5-phenyl-2-methoxy-4-methyl-1,3-thiazoline 
• 78374-02-4 cis-2-diethylamino-5-phenyl-4-methyl-1,3-thiazoline 
• 78374-00-2 cis-5-phenyl-2-phenylamino-4-methyl-1,3-thiazoline 
• 1630-31-5 cis-5-phenyl-4-methyl-1,3-thiazolidine-2-thione 
• 16251-45-9 4,5-trans-4-Methyl-5-phenyl-1,3-oxazolidin-2-one 
• 78393-88-1 threo-1-chloro-1-phenyl-2-isothiocyanatopropane 
• 78374-00-2 trans-5-phenyl-2-phenylamino-4-methyl-1,3-thiazoline 
• 78374-02-4 trans-2-diethylamino-5-phenyl-4-methyl-1,3-thiazoline 
• 78373-96-3 trans-5-phenyl-2-methoxy-4-methyl-1,3-thiazoline 
• 1630-31-5 trans-5-phenyl-4-methyl-1,3-thiazolidine-2-thione 

Relevant academic research and scientific papers

From the production of amphetamine phenylpropanolamine

A process for making compound of formula Ifrom a phenylpropanolamine salt of formula IIwherein:R1 is hydrogen or a lower alkyl group;each R2 is independently a hydrogen, halogen, lower alkyl group, lower alkoxy groups, lower alkyl group substituted with 1 to 5 halogens, lower alkoxy groups substituted with 1 to 5 halogens, or both R2 together when on adjacent carbons constitute a -O(CH2)xO- where x is 1 to 4, thereby forming a ring structure fused with the phenyl group;R3 is a C1-C8-alkyl group, a C1-C12-aralkyl group, C1-C12-alkaryl group, or a phenyl group, each optionally substituted by 1 to 5 substituents selected from halogen, hydroxy, or C1-C6-alkyl; andHX is an equivalent of an organic or inorganic acid,the process comprising:(a) acylating the phenylpropanolamine salt of formula II with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt of formula III which can be isolated by the addition of a crystallization solvent, or optionally this mixture can be used in the next step; and(b) hydrogenating the O-acylated phenylpropanolamine salt to make the compound of formula I in the presence of a catalyst.

STEREOCHEMICAL COURSE OF THE REACTION OF 2-HALOETHYL ISOTHIOCYANATES WITH NUCLEOPHILES. sTEREOSPECIFIC ROUTE TO 4,5-DISUBSTITUTED Δ2-THIAZOLINES AND THIAZOLIDINE-2-THIONES

Diastereoisomeric 1-chloro-1-phenyl-2-isothiocyanatopropanes have been prepared.They reacted stereospecifically with CH3ONa, diethylamine, aniline and NaSH to give pure cis or trans-4,5-disubstituted Δ2-thiazolines and thiazolidine-2-thiones whose configuration was determined using the nuclear Overhauser effect.The preponderant conformation of diastereoisomeric 1-chloro-1-phenyl-2-isothiocyanatopropanes was estimated on the basis of coupling constants of vicinal protons.