4380-71-6

Basic information

• Product Name: Benzamide, N-(2-hydroxy-1-methyl-2-phenylethyl)-
• CAS NO: 4380-71-6
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol File: 4380-71-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(2-hydroxy-1-methyl-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-hydroxy-1-methyl-2-phenylethyl)-(4380-71-6)
• EPA Substance Registry System: Benzamide, N-(2-hydroxy-1-methyl-2-phenylethyl)-(4380-71-6)

Safety Data

• Hazardous Substances Data: 4380-71-6(Hazardous Substances Data)

Upstream product

• 16735-29-8 N-(1-oxo-1-phenylpropan-2-yl)benzamide 
• 48115-38-4 norepinephrine 
• 98-88-4 benzoyl chloride 
• 154-41-6 erythro-1-phenyl-1-hydroxy-2-propylammonium chloride 
• 16735-19-6 2-amino-1-phenylpropan-1-one hydrochloride 
• 100-52-7 benzaldehyde 
• 26251-08-1 2-nitro-1-phenylpropan-1-ol 
• 119-51-7 1-phenyl-1,2-propanedione 2-oxime 
• 532-28-5 (RS)-mandelonitrile 
• 38222-78-5 benzoic acid-((1RS,2SR)-2-amino-1-phenyl-propyl ester); hydrochloride 
• 67-56-1 methanol 
• 154-41-6 norephedrine hydrochloride 
• 613-90-1 benzoyl cyanide 
• 14838-15-4 u-2-amino-1-phenylpropan-1-ol 

Downstream Products

• 1630-31-5 cis-5-phenyl-4-methyl-1,3-thiazolidine-2-thione 
• 1592-59-2 threo-1-chloro-1-phenyl-2-propylammonium chloride 
• 1592-59-2 erythro-1-chloro-1-phenyl-2-propylammonium chloride 
• 154-41-6 threo-1-phenyl-1-hydroxy-2-propylammonium chloride 
• 78374-00-2 cis-5-phenyl-2-phenylamino-4-methyl-1,3-thiazoline 
• 78374-00-2 trans-5-phenyl-2-phenylamino-4-methyl-1,3-thiazoline 
• 78374-02-4 cis-2-diethylamino-5-phenyl-4-methyl-1,3-thiazoline 
• 78374-02-4 trans-2-diethylamino-5-phenyl-4-methyl-1,3-thiazoline 
• 78373-96-3 cis-5-phenyl-2-methoxy-4-methyl-1,3-thiazoline 
• 78373-96-3 trans-5-phenyl-2-methoxy-4-methyl-1,3-thiazoline 
• 78393-88-1 threo-1-chloro-1-phenyl-2-isothiocyanatopropane 
• 78393-88-1 erythro-1-chloro-1-phenyl-2-isothiocyanatopropane 
• 1630-31-5 trans-5-phenyl-4-methyl-1,3-thiazolidine-2-thione 
• 39861-30-8 2-chloro-1-methyl-2-phenyl-ethylamine; hydrochloride 

Relevant articles and documents

Process for the preparation of optically active amino alcohols

Process for preparing optically active β-amino alcohols represented by a general formula (2): Ra—C*H(OH)—C*H(Rb)—Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one member select

Ruthenium-catalyzed oxidations for selective syntheses of ketones and acyl cyanides. Selective acylation of amino compounds with acyl cyanides

Oxidation of alcohols to the corresponding carbonyl compounds with tert-butyl hydroperoxide in the presence of dichlorotris(triphenylphosphine)ruthenium catalyst gives the corresponding carbonyl compounds with high efficiency. This method can be applied to the oxidation of cyanohydrins to give acyl cyanides which are versatile synthetic intermediates. Acylation of amino compounds with acyl cyanides thus obtained proceeds chemoselectively. Thus, the reaction of amino alcohols with acyl cynides gives N-acylated products exclusively. In the similar N-acylation of polyamines primary amines are selectively acylated in the presence of secondary amines. These reactions are highly useful for the synthesis of spermidine and spermine alkaloids such as spermidine alkaloids such as spermidine siderophores. Dimeric cyclocoupling reaction of diacyl cyanides such as iso- and terephthaloyl cyanides with polyamines can be performed under the similar reaction conditions to give the corresponding polyazamacrocycles with high efficiency.

NON-CATALYTIC REDUCTION OF Α-OXIMINOKETONES AND Α-OXIMINOALCOHOLS TO ERYTHRO-2-AMINO-1-ARYLALKAN-1-OLS

A non-catalytic reduction of α-oximinoketones 1 and α-oximinoalcohols 2 to erythro-2-amino-1-arylalkan-1-ols 3 with lithium aluminium hydride is reported.The erythro-2-amino-1-arylalkan-1-ols are isolated as their hydrochlorides 5 and characterised as the erythro isomers by benzoylation.