39884-19-0

Upstream product

• 39884-15-6 N-(5-acetyl-4-methylthiazol-2-yl)-4-nitrobenzamide 
• 30748-47-1 5-acetyl-4-methylthiazole-2-amine 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 39884-23-6 1-[4-methyl-2-(4-nitro-benzoylamino)-thiazol-5-yl]-2-morpholin-4-yl-ethanone 
• 1030631-36-7 C₂₀H₁₄ClN₅O₃S₂ 
• 39884-38-3 1-[4-methyl-2-(4-nitro-benzoylamino)-thiazol-5-yl]-2-morpholin-4-yl-ethanol 
• 39884-34-9 2-bromo-1-[4-methyl-2-(4-nitro-benzoylamino)-thiazol-5-yl]-ethanol 

Relevant academic research and scientific papers

4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing

The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library are reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy were assayed using epithelial cells expressing human ΔF508-CFTR. These structure-activity data establish that the bithiazole substructure plays a critical function; eight novel methylbithiazole correctors were identified with low micromolar potencies.