39892-24-5

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-chloro-ethyl)-pyridine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and medications.
Used in Agricultural Chemical Industry:
3-(2-chloro-ethyl)-pyridine is used as an intermediate in the production of pesticides, contributing to the creation of effective pest control agents.
Used in Organic Compounds Synthesis:
3-(2-chloro-ethyl)-pyridine is used as a building block in the synthesis of other organic compounds, leveraging its chemical properties to form a variety of products.
It is important to use proper protective equipment and adhere to safety protocols when working with 3-(2-chloro-ethyl)-pyridine due to its hazardous nature.

Upstream product

• 6293-56-7 3-pyridinylethanol 
• 497-19-8 sodium carbonate 
• 39998-25-9 methyl pyridine-3-acetate 
• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol "APLNR"). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) cardiovascular disease; (ii) metabolic disorders; (iii) diseases, disorders, and conditions associated with vascular pathology; and (iv) organ failure; (v) diseases, disorders, and conditions associated with infections (e.g., microbial infections); and (vi) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include pulmonary hypertension (e.g., PAH); heart failure; type II diabetes; renal failure; sepsis; and systemic hypertension.

Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones

The present invention relates to optionally substituted pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula I: STR1 wherein: Y is --CH2 -- or --C(O)--; R1 is hydrogen or --(CH2)n --R7, wherein: R7 is aryl or heteroaryl, and n is 1 or 2, provided that when Y is --C(O)--, R7 is heteroaryl; and R2, R3, R4, R5 and R6 are hydrogen, or one is selected from lower alkyl, halo, carboxy, methoxycarbonyl, carbamoyl, methylcarbamoyl, di-methylcarbamoyl, methylcarbonyl, methylthio, methylsulfinyl, methylsulfonyl, hydroxymethyl, amino, trifluoromethyl, cyano or nitro; or R2, R3, R4 and R5 are independently selected from hydrogen, lower alkyl, nitro, chloro, fluoro, methoxycarbonyl or methylcarbonyl, provided at least one is hydrogen, and R6 is hydrogen; or a pharmaceutically acceptable ester, ether or salt thereof.

[3-(Pyridinium)-7-(naphthyiridinyl carbonylamino)acetamido]cephalosporanic acid derivatives

7-[α-(4-hydroxy-1,5-naphthyridine-3-carboxamido)-α-phenyl or thienyl (and substituted phenyl) acetamido]-3-(pyridiniummethyl)-3-cephem-4-carboxylates having on the pyridine ring an acidic group which is preferably --COOH or --SO3 H and also, if desired, having one or two methylene groups together with or without a hetero atom between the pyridine ring and the acidic group were synthesized and found to have potent antibacterial activity in vitro especially against many strains of Pseudomonas aeruginosa and also high solubility in water.