39897-13-7

Basic information

• Product Name: (S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid
• Synonyms: (S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid
• CAS NO: 39897-13-7
• Molecular Weight: 255.295
• Mol File: 39897-13-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid(39897-13-7)
• EPA Substance Registry System: (S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid(39897-13-7)

Safety Data

• Hazardous Substances Data: 39897-13-7(Hazardous Substances Data)

Usage

General Description

"(S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid" is a chemical compound that belongs to the class of azetidine carboxylic acids. It has a chiral center and a sulfonyl group attached to the nitrogen atom. (S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid is commonly used in organic synthesis and pharmaceutical research as a starting material for the preparation of various drugs and biologically active molecules. The sulfonyl group enhances the reactivity and stability of the molecule, making it useful in a wide range of chemical reactions. Additionally, the presence of the azetidine ring and carboxylic acid functionality provides unique opportunities for the creation of diverse molecular scaffolds with potential pharmacological properties. Overall, "(S)-N-(p-toluenesulfonyl)azetidine-2-carboxylic acid" is a versatile compound with applications in both academic and industrial chemistry.

Upstream product

• 1022820-87-6 p-toluenesulfonylaminomalonic acid diethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 1414846-32-4 (S)-1-((S)-1-tosylazetidin-2-yl) ethane-1,2-diol 
• 1414846-31-3 (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)-1-tosylazetidine 
• 352018-64-5 (R)-4-N-(p-toluenesulfonyl)amino-2-chlorobutyric acid 
• 10396-97-1 4-methyl-N-((S)-2-oxotetrahydrofuran-3-yl)benzenesulfonamide 
• 960004-46-0 (S)-methyl 1-tosylazetidine-2-carboxylate 
• 2133-34-8 (2S)-azetidine-2-carboxylic acid 
• 2517-04-6 Azetidine-2-carboxylic acid 
• 10019-95-1 N-tosylpyrrolidinone 
• 178946-64-0 3-bromo-1-tosylpyrrolidin-2-one 
• 116283-38-6 2-[2-(Toluene-4-sulfonylamino)-ethyl]-malonic acid dimethyl ester 
• 116241-31-7 1-(Toluene-4-sulfonyl)-azetidine-2,2-dicarboxylic acid dimethyl ester 
• 116241-36-2 1-(Toluene-4-sulfonyl)-azetidine-2,2-dicarboxylic acid 

Downstream Products

• 2517-04-6 Azetidine-2-carboxylic acid 
• 554434-23-0 (S)-1-(Toluene-4-sulfonyl)-azetidine-2-carboxylic acid ((S)-1-hydroxymethyl-2-phenyl-ethyl)-amide 
• 960004-46-0 (S)-methyl 1-tosylazetidine-2-carboxylate 
• 17330-26-6 (1-tosylazetidin-2-yl)methanol 
• 868272-74-6 2-Diazo-1-[(S)-1-(toluene-4-sulfonyl)-azetidin-2-yl]-ethanone 

Relevant articles and documents

Inexpensive multigram-scale synthesis of cyclic enamines and 3-N spirocyclopropyl systems

Cyclic enamines are important synthons for many synthetic and pharmacological targets. Here, we report an inexpensive, catalyst-free, multigram-scale synthesis for cyclic enamines with exocyclic double bonds and four- to seven-membered rings. This strategy is more conducive to scale up, permissive of functionalization around the cyclic system, and less sensitive to the nature of the N-protecting group than previously-described methods for cyclic enamine synthesis. Further, we explore application of these enamines to the synthesis of highly-strained spirocyclic 3N-cyclopropyl scaffolds.

An efficient synthesis of azetidines with (2-bromoethyl)sulfonium triflate

Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure. The high-yielding reaction has a relatively broad scope and was extended to the synthesi

Thermal Arndt-Eistert reactions of N-tosyl cyclic α-amino acids

Thermal Arndt-Eistert reactions of N-tosyl cyclic α-amino acids were studied to explore the preparation of α,β-unsaturated esters bearing a terminal tosylamino group. For L-N-tosyl-aziridine 2-carboxylic acid and L-N-tosyl-azetidine 2-carboxylic acid, the corresponding (E)-α,β- unsaturated esters were obtained stereospecifically. Copyright Taylor & Francis, Inc.