399-44-0

Basic information

• Product Name: (2,4-DIFLUOROPHENOXY)ACETIC ACID
• Synonyms: (2,4-difluorophenoxy)acetic acid(SALTDATA: FREE);(2,4-DIFLUOROPHENOXY)ACETIC ACID;2-(2,4-difluorophenoxy)acetic acid;2-(2,4-difluorophenoxy)ethanoic acid
• CAS NO: 399-44-0
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.13
• Mol File: 399-44-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 298°Cat760mmHg
• Flash Point: 134°C
• Appearance: /
• Density: 1.414g/cm³
• Vapor Pressure: 0.000586mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: Refrigerator
• Solubility: DMSO (slightly), Methanol (Slightly)
• CAS DataBase Reference: (2,4-DIFLUOROPHENOXY)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-DIFLUOROPHENOXY)ACETIC ACID(399-44-0)
• EPA Substance Registry System: (2,4-DIFLUOROPHENOXY)ACETIC ACID(399-44-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 399-44-0(Hazardous Substances Data)

Usage

General Description

(2,4-DIFLUOROPHENOXY)ACETIC ACID is a synthetic organic compound that has a molecular structure consisting of a phenolic ring with two fluorine atoms attached at the 2 and 4 positions, and an acetic acid group attached to the phenolic ring. It is commonly used as a herbicide to control broadleaf weeds in various agricultural settings. The compound works by mimicking the action of the plant growth hormone auxin and causing uncontrolled growth in the targeted weeds, ultimately leading to their death. Despite its effectiveness as a herbicide, (2,4-DIFLUOROPHENOXY)ACETIC ACID has been the subject of controversy due to its potential negative impact on human health and the environment.

InChI:InChI=1/C8H6F2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 717-30-6 2-(2,4-difluorophenoxy)acetic acid ethyl ester 
• 367-25-9 2,4-difluorophenylamine 
• 367-27-1 2,4-difluorophenol 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 904702-73-4 O-methyl [(2-(2,4-difluorophenoxy)acetoxy)(4-methylphenyl)methyl]methylphosphinate 
• 904702-75-6 O-methyl [(2-(2,4-difluorophenoxy)acetoxy)(2,4-dichlorophenyl)methyl]methylphosphinate 
• 904702-70-1 O-methyl [(2-(2,4-difluorophenoxy)acetoxy)(2-chlorophenyl)methyl]methylphosphinate 
• 826990-56-1 [(2,4-difluorophenoxyacetyl)(ethoxycarbonyl)methylene]triphenylphosphorane 
• 826990-50-5 [(2,4-difluorophenoxyacetyl)(cyano)methylene]triphenylphosphorane 
• 189955-77-9 2-(2.4-Difluorophenoxy)acetic acid 2-methyl-1-(4-(methylsulfonyl) phenyl)propan-1-one-2-yl ester 
• 399-42-8 (2,4-difluoro-phenoxy)-acetyl chloride 
• 866145-65-5 O,O-dimethyl α-(2,4-difluorophenoxyacetoxy)-3-nitrobenzylphosphonate 
• 866145-63-3 O,O-dimethyl α-(2,4-difluorophenoxyacetoxy)benzylphosphonate 
• 366-98-3 (2,4-difluoro-phenoxy)-acetic acid-anhydride 
• 399-43-9 (2,4-difluoro-phenoxy)-acetic acid amide 
• 367-27-1 2,4-difluorophenol 

Relevant articles and documents

The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death

Tumor microenvironment is a complex multistep event which involves several hallmarks that transform the normal cell into cancerous cell. Designing the novel antagonistic molecule to reverse the tumor microenvironment with specific target is essential in modern biological studies. The novel 4-phenyl-2-phenoxyacetamide thiazole analogues 8a-ab were synthesized in multistep process, then screened and assessed for cytotoxic and anti-proliferative effects in vitro against multiple cancer cells of different origin such as MCF-7, A549, EAC and DLA cells which revealed that compound 8f with fluoro and methyl substitute has potential cytotoxic efficacy with an average IC50 value of ? 13 μM. The mechanism of cytotoxicity assessed for anti-tumor studies both in ascites and solid tumor models in-vivo inferred the regressed tumor activity. This is due to changes in the cause of tumor microenvironment with crackdown of neovascularization and evoking apoptosis process as assessed by CAM, corneal vascularization and apoptotic hallmarks in 8f treated cells. The molecular gene studies inferred involvement of HIF-1upregulation and stabilization of p53 which are interlinked in signaling as conferred by immunoblot analysis.

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Synthesis and herbicidal activity of [(Substituted Phenoxyacetoxy) (Substituted Phenyl)Methyl](Methyl) phosphinates containing fluorine

A series of [(substituted phenoxyacetoxy)(substituted phenyl)methyl] (methyl)phos- phinates containing fluorine were designed and synthesized. All the synthesized compounds were identified by elemental analysis, IR, 1H NMR, mass spectrometry. O-methyl [(2-fluorophenoxyacetoxy)(2,4- dichlorophenyl)methyl](methyl)phosphinate was further analyzed by X-ray single-crystal diffraction. Their herbicidal activity against a set of weed species was examined. Some of the compounds showed potential herbicidal activity, which provided some indications for further studies on structure modification. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.