399-66-6

Usage

Uses

Used in Pharmaceutical Industry:
(1,2,4)Triazolo(1,5-a)pyrazine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of novel drug candidates with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, (1,2,4)Triazolo(1,5-a)pyrazine is utilized as a building block for the creation of new agrochemicals, potentially enhancing crop protection and yield through targeted pest control.
Used in Materials Science:
(1,2,4)Triazolo(1,5-a)pyrazine is employed as a component in the development of advanced materials, leveraging its structural and chemical properties to achieve specific material characteristics for various applications.
Used in Organic Electronics:
(1,2,4)Triazolo(1,5-a)pyrazine is used in the field of organic electronics as a constituent in the design of organic semiconductors, which are crucial for the fabrication of flexible electronic devices and other innovative technologies.
Overall, the diverse applications of (1,2,4)Triazolo(1,5-a)pyrazine underscore its significance in multiple industries, reflecting its potential to contribute to scientific advancements and technological innovations.

InChI:InChI=1/C5H4N4/c1-2-9-5(3-6-1)7-4-8-9/h1-4H

Upstream product

• 1575612-94-0 (E)-N'-hydroxy-N-(pyrazin-2-yl)formimidamide 
• 51519-20-1 N'-hydroxy-N-(pyrazin-2-yl)formimidamide 
• 51519-20-1 C₅H₆N₄O 
• 51519-09-6 N,N-dimethyl-N'-(pyrazin-2-yl)formamidine 
• 51519-20-1 N-hydroxy-N'-pyrazin-2-ylimidoformamide 

Downstream Products

• 233278-56-3 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine 
• 1613021-91-2 (S)-N-(1-([1,2,4]-triazolo[1,5-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamide 
• 1575608-04-6 (2R,3R)-2-(2,4-difluorophenyl)-3-(5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 74803-31-9 8-anilino-1,2,4-triazolo<1,5-a>pyrazine 
• 74803-32-0 8-chloro-1,2,4-triazolo<1,5-a>pyrazine 
• 55366-16-0 8-hydrazino-[1,2,4]triazolo[1,5-a]pyrazine 

Relevant academic research and scientific papers

T3P-Mediated N-N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5- a]pyridines

Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]triazolo[1,5-a]pyridines from the corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering the triazolopyridines in good to excellent yields and purities.

Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility

Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity on the basis of the binding mode of albaconazole using molecular docking, along with SAR of antifungal triazoles. Tetrahydro-[1,2,4] triazolo[1,5-a]pyrazine and tetrahydro-thiazolo[5,4-c]pyridine nuclei were preferable to the other four fused-heterocycle nuclei investigated. Potent in vitro activity, broad spectrum and better water solubility were attained when triazoles containing nitrogen aromatic heterocycles were attached to these two nuclei. The most potent compounds 27aa and 45x, with low hERG inhibition and hepatocyte toxicity, both exhibited excellent activity against Candida, Cryptococcus, and Aspergillus spp., as well as selected fluconazole-resistant strains. A high water-soluble compound 58 (the disulfate salt of 45x) displayed unsatisfactory in vivo activity because of its poor PK profiles. Mice infected with C.alb. SC5314 and C.alb. 103 (fluconazole-resistant strain) and administered with 27aa displayed significantly improved survival rates. 27aa also showed favorable pharmacokinetic (PK) profiles.

CXCR7 ANTAGONISTS

Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives of the general formula (I'); processes for their preparation, medicaments containing these compounds, and the use of substituted sulfonamide derivatives for the preparation of medicaments

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors

Various β-amino amides containing triazolopiperazine heterocycles have been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. These compounds display excellent oral bioavailability and good overall phar

AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.