39901-46-7Relevant academic research and scientific papers
An efficient synthesis of symmetric and unsymmetric bis-(β- aminoamides) via Ugi multicomponent reaction
La Spisa, Fabio,Feo, Alberto,Mossetti, Riccardo,Tron, Gian Cesare
, p. 6044 - 6047 (2012)
A library of symmetrical and unsymmetrical bis-(β-aminoamides) has been prepared starting from symmetrical secondary diamines by using a double Ugi four-component reaction. A sacrifical Mumm rearrangement, thanks to the use of 2-hydroxymethyl benzoic acid, is necessary to suppress the competing split-Ugi reaction, increasing the yield and simplifying the purification step. The scope, the reaction conditions, and the role of water in trapping the nitrilium intermediate are also discussed.
