399030-99-0 Usage
General Description
6-Methoxy-D-tryptophan is a chemical compound that belongs to the tryptophan family and contains a methoxy group. It is a derivative of the amino acid tryptophan and is utilized in the production of various pharmaceuticals and biologically active compounds. 6-Methoxy-D-tryptophan has been studied for its potential therapeutic effects, including its role in neurotransmitter regulation and as a precursor for the synthesis of serotonin and other neuroactive molecules. It has also been investigated for its anti-inflammatory and antioxidant properties, as well as its potential applications in the treatment of neurodegenerative diseases and cancer. Overall, 6-Methoxy-D-tryptophan shows promise for a range of therapeutic uses and continues to be a subject of research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 399030-99-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,9,0,3 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 399030-99:
(8*3)+(7*9)+(6*9)+(5*0)+(4*3)+(3*0)+(2*9)+(1*9)=180
180 % 10 = 0
So 399030-99-0 is a valid CAS Registry Number.
399030-99-0Relevant articles and documents
One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase
Parmeggiani, Fabio,Rué Casamajo, Arnau,Walton, Curtis J. W.,Galman, James L.,Turner, Nicholas J.,Chica, Roberto A.
, p. 3482 - 3486 (2019/04/13)
d-Tryptophan and its derivatives are important precursors of a wide range of indole-containing pharmaceuticals and natural products. Here, we developed a one-pot biocatalytic process enabling the synthesis of d-tryptophans from indoles in good yields and high enantiomeric excess (91% to >99%). Our method couples the synthesis of l-tryptophans catalyzed by Salmonella enterica tryptophan synthase with a stereoinversion cascade mediated by Proteus myxofaciens l-amino acid deaminase and an aminotransferase variant that we engineered to display native-like activity toward d-tryptophan. Our process is applicable to preparative-scale synthesis of a broad range of d-tryptophan derivatives containing electron-donating or -withdrawing substituents at all benzene-ring positions on the indole group.
