39923-99-4

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 62-55-5 thioacetamide 
• 65032-59-9 bis-(4-nitro-benzoyl)-disulfane 
• 50338-08-4 S-trityl 4-nitrobenzothioate 

Downstream Products

• 39923-98-3 p-Nitrobenzoyl-benzyloxycarbonylsulfid 
• 41118-57-4 Benzoyl-p-nitrobenzoyldithiosulfit 
• 61268-11-9 C₈H₇NO₅S₂ 
• 61268-12-0 C₉H₉NO₅S₂ 
• 61268-14-2 C₁₀H₁₁NO₅S₂ 
• 61268-13-1 C₁₀H₁₁NO₅S₂ 
• 39924-01-1 p-Nitrobenzoyl-benzylthiocarbonylsulfid 
• 61268-15-3 C₁₃H₉NO₅S₂ 
• 61268-16-4 C₁₄H₁₁NO₅S₂ 
• 61268-17-5 C₁₅H₁₃NO₅S₂ 
• 41118-60-9 C₁₅H₁₁NO₆S₃ 
• 39924-02-2 bis(4-nitrobenzoyl) sulfide 
• 41118-52-9 C₁₄H₈N₂O₇S₃ 
• 50684-57-6 S-methyl p-nitrobenzothioate 

Relevant academic research and scientific papers

A facile synthesis of thioacids by hydrolysis of 1-(acylthio)ethaniminium chlorides

A facile method for the preparation of thioacids in moderate to good yields has been developed by hydrolysis of 1-(acylthio)ethaniminium chlorides under a liquid-liquid two phase system consisting of benzene and a sodium hydroxide aqueous solution at room temperature. We have achieved facile preparation of these compounds without use of toxic compounds such as hydrogen sulfide.

Atmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes

A mild, metal-free, atmospheric oxygen-mediated radical hydrothiolation of alkenes (and alkyne) is reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atmospheric oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnish a range of functionalized products. Biomolecules proved tolerant to the conditions and the procedure is robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirm the process proceeds through radical intermediates in a thiol-ene reaction manifold. The methodology offers an efficient “green” approach for thiol-ene mediated “click” ligation and a milder alternative to thermally initiated hydrothiolation processes.

Fast and highly chemoselective alkynylation of thiols with hypervalent iodine reagents enabled through a low energy barrier concerted mechanism

Among all functional groups, alkynes occupy a privileged position in synthetic and medicinal chemistry, chemical biology, and materials science. Thioalkynes, in particular, are highly useful, as they combine the enhanced reactivity of the triple bond with a sulfur atom frequently encountered in bioactive compounds and materials. Nevertheless, general methods to access these compounds are lacking. In this article, we describe the mechanism and full scope of the alkynylation of thiols using ethynyl benziodoxolone (EBX) hypervalent iodine reagents. Computations led to the discovery of a new, three-atom concerted transition state with a very low energy barrier, which rationalizes the high reaction rate. On the basis of this result, the scope of the reaction was extended to the synthesis of aryl- and alkyl-substituted alkynes containing a broad range of functional groups. New sulfur nucleophiles such as thioglycosides, thioacids, and sodium hydrogen sulfide were also alkynylated successfully to lead to the most general and practical method yet reported for the synthesis of thioalkynes.