39925-35-4

Basic information

• Product Name: Benzenemethanesulfonic acid, a-(chlorocarbonyl)-, (R)-
• CAS NO: 39925-35-4
• Molecular Formula: C8H7ClO4S
• Molecular Weight: 234.66
• Mol File: 39925-35-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenemethanesulfonic acid, a-(chlorocarbonyl)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanesulfonic acid, a-(chlorocarbonyl)-, (R)-(39925-35-4)
• EPA Substance Registry System: Benzenemethanesulfonic acid, a-(chlorocarbonyl)-, (R)-(39925-35-4)

Safety Data

• Hazardous Substances Data: 39925-35-4(Hazardous Substances Data)

Upstream product

• 41360-32-1 racemic α-sulfophenylacetic acid 
• 39925-38-7 2-phenyl-2-sulfoacetic acid 

Downstream Products

• 77772-33-9 (6R)-3-hydroxymethyl-8-oxo-7t-((R)-2-phenyl-2-sulfo-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 62587-73-9 cefsulodin 
• 58569-36-1 Sulbenicillin 
• 28002-18-8 (2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt 
• 53775-20-5 1-[(6R)-2-carboxy-8-oxo-7t-((R)-2-phenyl-2-sulfo-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl]-pyridinium betaine 
• 52482-29-8 4-acetylamino-1-[(6R)-2-carboxy-8-oxo-7t-((R)-2-phenyl-2-sulfo-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl]-pyridinium betaine 
• 52482-30-1 1-[(6R)-2-carboxy-8-oxo-7t-((R)-2-phenyl-2-sulfo-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl]-4-(hydroxyimino-methyl)-pyridinium betaine 
• 793609-39-9 (6R)-8-oxo-7t-((R)-2-phenyl-2-sulfo-acetylamino)-3-pyridin-2-ylsulfanylmethyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 771417-46-0 (6R)-8-oxo-7t-((R)-2-phenyl-2-sulfo-acetylamino)-3-pyridin-4-ylsulfanylmethyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant articles and documents

Preparation method of sulbenicillin sodium

The invention discloses a preparation method of sulbenicillin sodium. According to the invention, L-amino acid is firstly adopted to perform splitting on D, L-sulfonylphenylacetic acid to obtain D(-)-sulfonylphenylacetic acid, then D(-)-sulfonylphenylacetic acid is compounded with D, L-sulfonylphenylacetic acid to prepare a sulfonylphenylacetic acid mixture with D(-)-sulfonylphenylacetic acid to L(+)-sulfonylphenylacetic acid ratio being about 78%:22%, the sulfonylphenylacetic acid mixture is chlorinated and then reacts with 6-APA, and then reacts with sodium iso-octoate, to directly obtain asulbenicillin sodium mixture with the ratio of D(-)-sulbenicillin sodium to L(+)-sulbenicillin sodium being about 78%:22%. According to the invention, post-treatment process is simplified, no water isused in the step of producing sulbenicillin sodium, hydrolysis impurity level is reduced, product purity is more than 99.0%, and product mole rate is more than 90%.