58569-36-1

Basic information

• Product Name: Sulbenicillin
• Synonyms: Sulbenicillin
• CAS NO: 58569-36-1
• Molecular Weight: 414.46
• Mol File: 58569-36-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Sulbenicillin(CAS DataBase Reference)
• NIST Chemistry Reference: Sulbenicillin(58569-36-1)
• EPA Substance Registry System: Sulbenicillin(58569-36-1)

Safety Data

• Hazardous Substances Data: 58569-36-1(Hazardous Substances Data)

Upstream product

• 551-16-6 6-Aminopenicillanic Acid 
• 39925-35-4 2-sulfo-2-phenylacetyl chloride 
• 19460-36-7 triethylammonium 6β-penicillanate 
• 39925-38-7 2-phenyl-2-sulfoacetic acid 
• 41360-32-1 racemic α-sulfophenylacetic acid 
• 40125-73-3 2-sulpho-2-phenylacetyl chloride 

Downstream Products

• 28002-18-8 (2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt 

Relevant articles and documents

Preparation method of sulbenicillin sodium

The invention discloses a preparation method of sulbenicillin sodium. According to the invention, L-amino acid is firstly adopted to perform splitting on D, L-sulfonylphenylacetic acid to obtain D(-)-sulfonylphenylacetic acid, then D(-)-sulfonylphenylacetic acid is compounded with D, L-sulfonylphenylacetic acid to prepare a sulfonylphenylacetic acid mixture with D(-)-sulfonylphenylacetic acid to L(+)-sulfonylphenylacetic acid ratio being about 78%:22%, the sulfonylphenylacetic acid mixture is chlorinated and then reacts with 6-APA, and then reacts with sodium iso-octoate, to directly obtain asulbenicillin sodium mixture with the ratio of D(-)-sulbenicillin sodium to L(+)-sulbenicillin sodium being about 78%:22%. According to the invention, post-treatment process is simplified, no water isused in the step of producing sulbenicillin sodium, hydrolysis impurity level is reduced, product purity is more than 99.0%, and product mole rate is more than 90%.