3994-24-9

Usage

InChI:InChI=1/C11H10ClN3O2/c1-2-17-11(16)10(7-13)15-14-9-5-3-8(12)4-6-9/h3-6,14H,2H2,1H3/b15-10-

Upstream product

• 20265-96-7 p-chloroaniline hydrochloride 
• 105-56-6 ethyl 2-cyanoacetate 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 126362-27-4 3-{3-Amino-4-[(4-chloro-phenyl)-hydrazono]-5-oxo-4,5-dihydro-pyrazol-1-yl}-propionitrile 
• 134340-80-0 Cyano-[(5,5'-dichloro-2'-{N'-[1-cyano-1-ethoxycarbonyl-meth-(E)-ylidene]-hydrazino}-biphenyl-2-yl)-hydrazono]-acetic acid ethyl ester 
• 134340-79-7 C₂₂H₁₈Cl₂N₆O₄*2ClHO₄ 
• 126362-30-9 3-[3-Amino-4-(4-chloro-phenylazo)-2-(2-cyano-ethyl)-5-oxo-2,5-dihydro-pyrazol-1-yl]-propionitrile 
• 126362-33-2 3-[3-(4-Chloro-phenylazo)-2,5-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[1,5-a]pyrimidin-1-yl]-propionitrile 
• 90272-29-0 Cyanglyoxylsaeurechlorid-4-chlorphenylhydrazon 
• 76043-32-8 3-amino-4-(2-(4-chlorophenyl)hydrazono)-1H-pyrazol-5(4H)-one 
• 63519-81-3 3-amino-4-(2-(4-chlorophenyl)hydrazono)-1-phenyl-1H-pyrazol-5(4H)-one 

Relevant academic research and scientific papers

Reaction of (chloro carbonyl) phenyl ketene with 5-amino pyrazolones: Synthesis, characterization and theoretical studies of 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives

New 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives were synthesized from the reaction of (chlorocarbonyl)phenyl ketene and 5-amino pyrazolones in high to excellent yields and short reaction times. Structures of

Phenyl hydrazone bearing pyrazole and pyrimidine scaffolds: Design and discovery of a novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) against HIV-1 and their antibacterial properties

A novel series of phenyl hydrazone bearing pyrazole and pyrimidine hybrid compounds has been designed using the molinspiration toolkit based on Lipinski's rule of five and developed via sequential reactions starting from the diazotization of different anilines and further active methylation with acetyl acetone, ethyl acetoacetate and ethyl cyanoacetate to generate hydrazono derivatives. The target hybrid compounds were synthesized on cyclisation of the resulting hydrazono derivatives with hydrazine, phenyl hydrazine and urea. These molecules have been subsequently tested for anti-HIV activity using TZM-bl cell lines. The MTT assay was also carried out for the cytotoxicity determination of the active compounds. Further, to exemplify the key structural features of the molecules, a molecular docking analysis of the most active compounds was performed at the NNIBP of the HIV-RT protein. The antibacterial activity of the target compounds was also determined against a panel of four Gram-positive and four Gram-negative human pathogens. All molecules showed a potent anti-HIV activity along with a prominent inhibition of bacterial organisms.

Kinetics and mechanism of dehydrochlorination of N-aryl-C-ethoxycarbonylformohydrazidoyl chlorides

The kinetics of triethylamine (TEA) catalyzed dehydrochlorination of a series of N-aryl-C-ethoxycarbonylformohydrazidoyl chlorides 1a-m have been studied under pseudo-first-order conditions in 4:1 (v/v) dioxane-water solution at 30 deg C.For all compounds

SYNTHESIS OF AZOLOYL KETONE AND AZOLOYLACETIC ACID DERIVATIVES: REACTIONS OF 4-ARYLAZO-2-OXAZOLIN-5-ONES WITH ACTIVE METHYLENE COMPOUNDS

The rearrangement of 4-arylazo-2-oxazolin-5-ones (1) with active methylene compounds was investigated.The 1,2,4-triazolyl derivatives (11) could be obtained on treatment of 1 with 2-pyrazolin-5-one derivatives.The behaviour of the synthesized derivatives