39943-61-8

Basic information

• Product Name: (3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE
• Synonyms: Hydrazine, (3,5-dimethylphenyl)-
• CAS NO: 39943-61-8
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.1943
• Mol File: 39943-61-8.mol

Chemical Properties

• Boiling Point: 247.3°Cat760mmHg
• Flash Point: 118.6°C
• Appearance: /
• Density: 1.058g/cm³
• Vapor Pressure: 0.0259mmHg at 25°C
• Refractive Index: 1.607
• PKA: 5.51±0.10(Predicted)
• CAS DataBase Reference: (3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE(39943-61-8)
• EPA Substance Registry System: (3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE(39943-61-8)

Safety Data

• Hazardous Substances Data: 39943-61-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE is used as an anti-tumor agent for its potential to inhibit the growth of cancer cells. It has shown promising results in studies and is being investigated for its effectiveness in treating various types of cancer.
Used in Research Industry:
(3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE is used as a research compound for studying its potential biological and therapeutic properties. It is being investigated for its potential use as an anti-inflammatory agent and its effects on various biological processes.
It is important to handle (3,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE with caution as it is potentially hazardous and can cause irritation to the skin, eyes, and respiratory system. Proper safety measures and protocols should be followed when working with this chemical compound.

InChI:InChI=1/C8H12N2/c1-6-3-7(2)5-8(4-6)10-9/h3-5,10H,9H2,1-2H3

Upstream product

• 70638-32-3 3,5-Dimethyl-benzenediazonium; chloride 
• 108-69-0 3,5-dimethylaminoaniline 
• 60481-36-9 (3,5-dimethylphenyl)hydrazine hydrochloride 
• 556-96-7 5-bromo-1,3-xylene 

Downstream Products

• 1416983-48-6 C₁₅H₁₈N₂O₂S 
• 79238-62-3 diethyl (3’,5’-dimethyl)phenylphosphonate 
• 474352-67-5 2-(3, 5-dimethylphenyl)-2H-indazole 
• 1609385-80-9 1-(3,5-dimethylphenyl)-1H-1,2,4-triazole 
• 33555-22-5 4,6-dimethyl-2-phenylindole 

Relevant articles and documents

First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO)

We show that changing the number and position of nitrogen atoms in the heteroatomic core of a pyrazolopyrimidine acetamide is sufficient to induce complex binding to wild type human TSPO. Only compounds with this complex binding profile lacked intrinsic effect on glioblastoma proliferation but positively modulated the antiproliferative effects of a synthetic TSPO ligand. To the best of our knowledge this is the first demonstration of allosteric-like interaction at the wild type human TSPO.

Efficient synthesis of aryl hydrazines using copper-catalyzed cross-coupling of aryl halides with hydrazine in PEG-400

An efficient and convenient method for the synthesis of aryl hydrazines is described via copper-catalyzed cross-coupling of aryl halides with aqueous hydrazine in PEG-400. This protocol is applicable to both electron-deficient and electron-rich aryl iodides and bromides, and even to sterically hindered substrates, giving aryl hydrazines in good to excellent yields.

NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The invention relates to substituted pyrazolo[3,4-d]pyrimidine derivatives of the Formula-(I), or pharmaceutically acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted pyrazolo[3,4-d]pyrimidine derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro: (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.