399512-85-7Relevant academic research and scientific papers
A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: An efficient construction of a multi-substituted 3: H -spiro[benzofuran-2,1′-cyclopentane] skeleton
Liu, Lin,Lei, Lin-Sheng,Zhan, Zong-Song,Liu, Si-Zhan,Wang, Yu-Xiao,Tu, Yong-Qiang,Zhang, Fu-Min,Zhang, Xiao-Ming,Ma, Ai-Jun,Wang, Shao-Hua
, p. 3789 - 3792 (2019)
A facile and efficient method to form a chiral multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] structural unit has been developed via a one-pot [3+2] cyclization/semipinacol rearrangement cascade. A catalysis system of Cu(ii)/BOX has been used to efficiently construct a key stereogenic center via a cyclization between substituted benzoquinones and allylic alcohols affording the desired products in good yields and with excellent enantioselectivities and diastereoselectivities (21 examples; up to 67% yields; up to 92% ee and up to >20:1 dr). This method provides an alternative strategy for the synthesis of the corresponding bioactive molecules containing spiro[benzofurancyclopentane] skeleton units.
Facile and inexpensive synthesis of α,β,β'-deuterated liquid crystalline and classical acrylate monomers
Keller,Thomsen III,Li
, p. 581 - 584 (2007/10/03)
An inexpensive synthesis of 2H3-labeled acrylate monomers was presented. Multistep routes to prepare deuterated side-end and side-on liquid crystalline acrylate monomers were presented. The level of deuterium incorporation in the syn
