39964-98-2

Upstream product

• 269-44-3 papraline 
• 151-50-8 potassium cyanide 
• 98-88-4 benzoyl chloride 
• 55976-49-3 N-(1-benzo[1,3]dioxol-5-yl-2-phenyl-ethyl)-N-(2,2-dimethoxy-ethyl)-toluene-4-sulfonamide 
• 55857-74-4 5-benzyl-6-(toluene-4-sulfonyl)-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 39964-90-4 N-(2,2-dimethoxyethyl)-N-<(3,4-methylenedioxyphenyl)methyl>-p-toluenesulfonamide 

Downstream Products

• 16658-48-3 Escholamin 
• 66879-36-5 6-benzoyl-5-(2-nitro-benzyl)-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 66879-35-4 6-benzoyl-5-benzyl-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 38750-42-4 6-benzoyl-5-(3-benzyloxy-4-methoxy-benzyl)-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 70400-69-0 6-benzoyl-5-(3-benzyloxy-4-methoxy-2-nitro-benzyl)-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 61306-98-7 6,6'-dibenzoyl-5,6,5',6'-tetrahydro-5,5'-(4-methoxy-3,4'-oxy-dibenzyl)-bis-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 269-44-3 papraline 
• 77620-01-0 6,7-methylenedioxyisoquinoline-1-carbonitrile 
• 38750-43-5 O-benzylisosevanine 
• 20353-85-9 1-benzoyl-6,7-methylenedioxyisoquinoline 
• 77619-98-8 5,6-dimethoxy-3-(6,7-methylenedioxyisoquinolin-1-yl)isobenzofuran-1(3H)-one 
• 77620-03-2 6,7-methylenedioxy-3-(6,7-methylenedioxyisoquinolin-1-yl)isobenzofuran-1(3H)-one 
• 123796-55-4 O-benzylberbithine 
• 1025823-93-1 6-Benzoyl-5-[(4-benzyloxy-benzo[1,3]dioxol-5-yl)-hydroxy-methyl]-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 

Relevant academic research and scientific papers

Protoberberines from Reissert-Compounds VIII [1]. Oxazoloisoquinolines, New and Efficient Educts for the Synthesis of 8-Oxoprotoberberines

Certain benzylated oxazoloisoquinolinones readily available from Reissert compounds provided an efficient access to 8-oxoprotoberberines in three steps. A series of these new precursors as well as several oxoprotoberberines were prepared and the scope and limitation of this procedure were investigated.

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

Syntheses of the Benzylisoquinoline Alkaloids Isosevanine and Berbithine

The benzylisoquinoline alkaloids isosevanine (1) and berbithine (2) have been synthesized by alkylation of the Reissert compound (5), derived from 6,7-methylenedioxyisoquinoline, with the appropriate benzyl chlorides (6) and (7) respectively followed by hydrogenolysis of the protecting group.