39986-45-3Relevant academic research and scientific papers
Inhibitors of human histone deacetylase: Synthesis and enzyme assay of hydroxamates with piperazine linker
Chakrabarty, Shubhashis,Jasmine,Bhadaliya, Chetan,Sinha, Barij Nayan,Mahesh, Aruna,Bai, He,Blond, Sylvie Y.,Jayaprakash, Venkatesan
experimental part, p. 167 - 172 (2010/08/05)
The histone deacetylase (HDAC) enzyme plays an important role in gene transcription. Inhibitors of histone deacetylases induce cell differentiation and suppress cell proliferation in tumor cells. Hydroxamates with rigid linker have displayed better inhibi
